Mississippi River Cruises aboard Queen of the Mississippi

Beneath Queen of the Mississippi's gleaming woodwork and polished brass is a framework of modern technology that provides passengers the most enjoyable Mississippi River cruise imaginable as our all-American crew delivers the personalized service that is the hallmark of American Cruise Lines.

7 Mississippi River Itineraries to Choose From:

New Orleans, LA to Memphis, TN

New Orleans, LA to New Orleans, LA

St. Louis, MO to St. Paul, MN

St. Louis, MO to Cincinnati, OH

Memphis, TN to St. Louis, MO

Memphis, TN to Nashville, TN

Nashville, TN to St. Louis, MO

Lower Mississippi River Cruise

from New Orleans, LA or Memphis, TN

This Lower Mississippi River cruise is a perfect getaway for the music enthusiast, history buff, and food aficionado in each of us. Join us this 8-day voyage from New Orleans to Memphis as we discover the historic and culturally rich ports of Natchez, Vicksburg and Oak Alley, LA.

Enjoy the South's legendary cuisine as local jazz musicians get your toes tappin' with their lively tunes.

Cruise Highlights: New Orleans, Oak Alley, Baton Rouge, St. Francisville, Natchez, Helena, and Memphis

Mississippi River Paddlewheel Cruise

New Orleans, LA

Explore the iconic cities of New Orleans, Baton Rouge and Oak Alley, LA on this 8-day, round-trip paddlewheel cruise from New Orleans, LA.

Discover the history of “the Big Easy”, the romance of Natchez, or pay tribute to the blue and gray at Vicksburg National Military Park.

Enjoy legendary Southern hospitality for yourself with guided shore excursions and fine regional cuisine prepared by highly acclaimed chefs.

Cruise Highlights: New Orleans, Natchez, Vicksburg, St. Francisville, Baton Rouge, and Oak Alley, LA

Upper Mississippi River Cruise

from St. Louis, MO or St. Paul, MN

Cruise the upper Mississippi River on an 8-day voyage from St. Louis to St. Paul aboard the stunning, new Queen of the Mississippi paddlewheeler.

From tranquil towns and bustling cities to impressive locks and dams, adventure is around every corner. Pilot a river barge at the Dubuque’s Mississippi River Museum, dance to Scandinavian folk tunes at the Norwegian Heritage Center in La Crosse, or explore the heart of Amish Country.

Cruise Highlights: St. Louis, Alton, Hannibal, Burlington, Davenport, Dubuque, La Crosse, Winona, Red Wing, and St. Paul

from St. Louis or Cincinnati, OH

Cruise the Mississippi and Ohio Rivers from St Louis to Cincinnati, OH aboard the Queen of the Mississippi. Beneath this incredible paddlewheeler’s gleaming brass is a framework of modern technology that provides spacious accommodations and the most comfortable cruising experience imaginable. 

Join us as we explore the historic ports of St. Louis, Louisville, and Mount Vernon on this 8 day paddlewheel cruise.

Cruise Highlights: St. Louis, Paducah, Cave in Rock, Henderson, Mt. Vernon, Louisville, Madison, and Cincinnati

Mississippi Paddlewheel Riverboat Cruise

from Memphis, TN to St. Louis, MO

Step back in time and enjoy the rhythm of the Mississippi River aboard an 8-day cruise from Memphis, TN to St. Louis, MO. From the great Gateway Arch, the country’s tallest man-made monument, to the exciting city of Memphis, famous for its blues, barbeque, and Graceland, you’ll travel a little slower.

Between these two great cities you’ll cruise on the Mississippi River and explore Civil War and Underground Railroad sites, visit the most haunted city in America, and discover quintessential small-town America.

Cruise Highlights: St. Louis, Alton, Cape Girardeau, Paducah, Columbus, New Madrid, Tunica, and Memphis