American Cruise Lines brand new authentic paddlewheeler, Queen of the Mississippi, sets a new standard for cruising the Mississippi River. The new Mississippi riverboat beautifully blends nineteenth century grandeur with all the comforts and amenities of modern technology. Spacious staterooms, private balconies, seven unique lounges, and a grand single seating dining room all provide you with plenty of space to relax. With only 150 guests onboard, the crew on Queen of the Mississippi will provide you with an unprecedented level of personalized service. To cruise the Mississippi River aboard the Queen of the Mississippi is to experience Mark Twain’s river in a refined atmosphere that is only possible with American Cruise Lines.

New Orleans - Memphis Cruise

Eight-Day / Seven-Night Cruise
Departing from New Orleans, LA or Memphis, TN

This cruise along the lower Mississippi River is perfect for music enthusiasts, history buffs, and food aficionados alike. Our highly skilled chefs will introduce you to some of South's most legendary dishes and local musicians will get your toes tappin' with their lively tunes. Along the way, you will discover some of the most historic and culturally rich areas along the Mississippi River, including historic Natchez, Civil War era Vicksburg and Oak Alley, one of the Old South's most legendary plantations.

New Orleans, Oak Alley, Baton Rouge, St. Francisville, Natchez, Helena, Memphis

New Orleans Round Trip Cruise

Eight-Day / Seven-Night Cruise
Departing from New Orleans, LA

This is a land of bayous and southern belles. From legendary jazz to the “grande dame” of all plantation homes, immerse yourself in the heritage of the Old South while cruising the Mississippi River. Discover romance in the quaint historic district of Natchez, or pay tribute to the blue and gray at the Vicksburg National Military and Park.

Ports of Call: New Orleans, Natchez, Vicksburg, St. Francisville, Baton Rogue, Oak Alley 

St. Louis - St. Paul Cruise

Eight-Day / Seven-Night Cruise
Departing from St. Louis, MO or St. Paul, MN

Journey through America’s Heartland from tranquil towns and bustling cities to impressive locks and dams. Adventure is around every corner whether you choose to pilot a river barge at the Dubuque’s Mississippi River Museum, dance to Scandinavian folk tunes at the Norwegian Heritage Center in La Crosse, or explore the heart of Amish Country.

Ports of Call: St. Louis, Alton, Hannibal, Burlington, Davenport, Dubuque, La Crosse, Winona, Red Wing, St. Paul 

St. Louis - Cincinnati Riverboat Cruise

Eight-Day / Seven-Night Cruise
Departing from St. Louis, MO or Cincinnati, OH

Departing from St. Louis, cruise the Mississippi to the Ohio River. As you travel along the Mississippi River, you will discover a world that has gone unchanged, representing a much simpler time. Considered one of America’s most picturesque waterways, the Ohio River is known for its awe-inspiring scenery, and quaint towns. Tour vibrant Louisville, best known for the famed Kentucky Derby and Triple Crown, and in Henderson see John James Audubon’s famous “Birds of America” series.

Ports of Call: St. Louis, Paducah, Cave in Rock, Henderson, Mt. Vernon, Lousiville, Madison, Cincinnati

Cincinnati - Pittsburgh Riverboat Cruise

Eight-Day / Seven-Night Cruise
Departing from Cincinnati, OH or Pittsburgh, PA

Follow the route of brave explorers seeking fame and fortune on the world’s first steamboats. This unique cruise takes you along the western edge of the Appalachian Mountains, through a landscape of rolling hills with impressive mountains in the distance. Quaint river towns dot the river’s edge, featuring an eclectic collection of art galleries, specialty shops, and museums.

Ports of Call: Cincinnati, Maysville, Portsmouth, Gallipolis, Point Pleasant, Marietta, Wheeling, Pittsburgh

Memphis - St. Louis Cruise

Eight-Day / Seven-Night Cruise
Departing from Memphis, TN or St. Louis, MO

From the great Gateway Arch, the country’s tallest man-made monument, to the exciting city of Memphis, famous for its blues, barbeque, and Graceland, you’ll travel a little slower, stepping back in time, enjoying the rhythm of the Mississippi River. Between these two great cities you’ll cruise on the Mississippi and explore Civil War and Underground Railroad sites, visit the most haunted city in America, and discover quintessential small-town America.

Ports of Call: St. Louis, Alton, Cape Girardeau, Paducah, Columbus, New Madrid, Tunica, Memphis