Grand Heartland Cruise

Fifteen-Day / Fourteen Night Mississippi River cruise
Departing from St. Paul, MN

Enjoy an epic 15-day/14-night journey on our Grand Heartland cruise. This cruise on the Mississippi River travels from the northern reaches in St. Paul, MN all the way down to the basin in New Orleans, LA. Experience the American heartland the way early pioneers did and gain insight into this magnificent waterway. The Grand Heartland cruise offers guests a front row view to 10 states in one of the most comfortable paddlewheel cruise ships on the Mississippi. 

Ports of Call
: St. Paul, Red Wing, La Crosse, Dubuque, Davenport, Hannibal, St. Louis, Memphis, Vicksburg, Natchez, Baton Rouge and New Orleans

Click on Images Above to View Photo Gallery
  Journey the length of the Mississippi River on this extraordinary two week cruise from St. Paul, MN to New Orleans, LA.

Port of Call:

St. Paul, MN

Red Wing, MN

La Crosse, WI

Dubuque, IA

Davenport, IA

Hannibal, MO

St. Louis, MO

Memphis, TN

Vicksburg, TN

Natchez, MS

Baton Rouge, LA

New Orleans, LA

Day 1
St. Paul, MN

St. Paul Skyline

St. Paul is a thrilling place to begin your adventure on the Mississippi River. History buffs will enjoy a walking tour of Summit Avenue, which showcases gorgeous historic mansions built in the late 1800’s. St. Paul’s enchanting art galleries, world class museums, and entertaining stage performances will capture your imagination.

Day 2
Red Wing, MN

Discover Minnesota on Mississippi River Cruise

Nestled among the scenic bluffs of the upper Mississippi River, Red Wing's beauty has inspired artisans, craftspeople and artists for over 150 years. Red Wing delivers a diverse blend of arts, entertainment and activities for your pleasure. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.

Day 3
La Crosse, WI

Step into 19th century America in La Crosse, located on the banks of three captivating rivers. La Crosse is home to Riverside Park, where you’ll enjoy beautiful gardens, an outdoor performance center, and inspiring sculptures.

Day 4
Dubuque, IA

Dubuque lock and dam on Queen of the Mississippi upper river cruises

A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the Mississippi River. Dubuque is overflowing with things to do and see. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through a whimsical downtown area, and visit the national Mississippi River Museum and Aquarium.

Day 5
Davenport, IA

Mississippi Riverboat Cruise Excursions in Davenport, IA

Voted one of the Most Livable Small Cities in America, Davenport is often described by newcomers and life-long residents alike as a lively, active city with a hometown feel. This vibrant city features the Legacy of John Deere, the largest agricultural exhibit in the world. Music enthusiasts will enjoy Davenport’s many music festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival, which is dedicated to native jazz musician Bix Beiderbecke.

Day 6
Day of River Cruising

QOM Deck

Enjoy the day relaxing on the upper deck, or your private balcony as we cruise from Davenport, IA to Hannibal, MO.

Day 7
Hannibal, MO

Visit Mark Twain’s Home During Mississippi River Cruise

Hannibal, “America’s Hometown,” is a place where you can rediscover adventures from Mark Twain’s era. Tom Sawyer and Huck Finn are alive in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans filled with wonderful and special shops unique to Hannibal. No matter what you choose to do, you will find this town to be very accommodating.

Day 8
St. Louis, MO

St. Louis, Missouri Excursions During Mississippi River Cruise

St. Louis, known as the “Gateway to the West,” is sure to win you over. Take in the Gateway Arch Riverfront, highlighted by the majestic Gateway Arch, which is the largest manmade monument in the U.S. There’s something for everyone at St. Louis’ many world-class, free attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s top public gardens.

Day 9
Day of River Cruising

Mississippi River cruise from St. Louis to Memphis

Grab a good book and curl up in one of our spacious lounges, or grab a pair of binoculars and enjoy the fall foliage as we make our way down the Mississippi River.

Day 10
Memphis, TN

Elvis Presley's Cadillac

Excitement resonates as you reach America’s third-largest inland port, famous for blues, barbeque, and Elvis Presley's Graceland. Less-touted attractions, such as the Pink Palace and Mud Island’s River Walk, replicating 1,000 miles of Mississippi River history and geography along an intriguing six-block stroll, are just as intriguing. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop for it all. As you disembark, immerse yourself in the sights and sounds of one of the mid-South's most remarkable cities.

Day 11
Day of River Cruising

Mississippi River Paddlewheel cruises on the Queen of the Mississippi

Spend a beautiful day with friends in one of the ship's beautiful lounges as we explore the river from Memphis to Vicksburg.

Day 12
Vicksburg, MS

Vicksburg Military park on the Mississippi River Civil War cruiseAround every corner, U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil war battlefields, century old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and watch Vicksburg’s history come to life at the riverfront murals.

Day 13
Natchez, MS

Natchez Indian Girl

Overlooking the Mississippi River, Natchez was first established as a French fort site in 1716, later becoming part of the United States as the first capital of Mississippi in 1817. Perched over 200 feet above the Mississippi River with 30-mile views along the river both north and south, the bluff of Natchez is a place to marvel in the beauty and grandeur of the river. A quaint Southern town rich in culture, history, and known for its abundance of antebellum architecture, Natchez offers true southern hospitality with the attractions of a great small city.

Day 14
Baton Rouge, LA

Experience the wonder of Baton Rouge, Louisiana's capitol. Known as the Red Stick, Baton Rouge is home to legendary Louisiana Cajun cuisine, fascinating plantation tours, and a variety of attractions. There is everything you would expect to find in a state capital, but with a down-home flavor that is part of its seductive charm. Enjoy a grand tour of one of the most historic and unforgettable cities in the South.

Day 15
New Orleans, LA

Bourbon Street New Orleans on Mississippi River Cruises from New Orleans to Memphis

Welcome to New Orleans, commonly referred to as the Birthplace of Jazz. There is something for everyone with this city’s history, culture and arts prevalent around every corner. The open air artist colony proudly displays local artist’s works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve the city’s rich history. Consider staying an extra day or night to enjoy this lively city.

Mississippi River cruises video

Beneath the gleaming woodwork and brass fixtures aboard Queen of the Mississippi is a framework of modern cruise ship technology that provides passengers with the most comfortable vacation imaginable as we cruise the Mississippi and Ohio Rivers from New Orleans to Minneapolis or Cincinnati, OH. The Queen of the Mississippi features the most spacious staterooms in the industry and provides more space per passenger than any other river cruise ship.Click play to see more.

Date # of Nights Departure Location Ship
Aug 6, 2016 14 St. Paul, MN Queen of the Mississippi reserve now
Sep 10, 2016 14 St. Paul, MN America reserve now
Oct 15, 2016 14 St. Paul, MN Queen of the Mississippi reserve now
Sep 9, 2017 14 St. Paul, MN America reserve now
Oct 21, 2017 14 St. Paul, MN Queen of the Mississippi reserve now

Queen of the Mississippi

Queen of the Mississippi delivers an experience unlike any other riverboat. Queen of the Mississippi offers passengers modern amenities and comforts including large staterooms with private balconies, hotel-style bathrooms, complimentary room service, WiFi, and more. 
Rate Schedule Per Person A AAL AAC AAM Owner's Suite Single w/ Balcony Single
14 Nights $8,850 $11,515 $11,795 $12,235 $14,650 $13,375 $12,135

Rates subject to change


The America will be American Cruise Lines’ eighth ship and its second brand-new vessel this year. Scheduled to begin sailing the Mississippi River in early 2016, America will be the finest Mississippi paddlewheeler ever built, introducing features never before seen on a Mississippi riverboat.
Rate Schedule Per Person A AAL AAC AAM Owner's Suite Single w/ Balcony Single
14 Nights $8,850 $11,515 $11,795 $12,235 $14,650 $13,375 $12,135

Rates subject to change

Other Mississippi River Cruises

Upper Mississippi River Cruise

Eight Days cruising the dramatic landscapes of the upper Mississippi River, including stops in the iconic Davenport, MO and Hannibal, MO – Mark Twain’s childhood hometown.                                      


Lower Mississippi River Cruise

Enjoy an 8-day cruise through the bayou and Mississippi River delta exploring intruiging excursions at the National Military Park in Vicksburg and the Rosedown Plantation.


Memphis - St. Louis Cruise

Discover the rich heritage and history found along the banks of Tennessee aboard this traditional paddlewheel cruise travelling out of Memphis, TN- America’s third largest inland port.


Memphis - Nashville Cruise

Spend eight days travelling the Mississippi and Cumberland rivers from Memphis, TN to Nashville, KY, including stops in Paducah, KY; Dover, TN and Clarksville, TN.

Queen of the Mississippi Virtual Tour