Dates & Fares for Grand Ohio River Cruise

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16 Days - 15 Nights One Way 11 Ports

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Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Jun 20, 2025
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $0
SOLD OUT
  • American Melody | American Riverboat
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from St. Louis, MO to Pittsburgh, PA
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Aug 15, 2025
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $8,740
SOLD OUT
  • American Melody | American Riverboat
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from Pittsburgh, PA to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Aug 22, 2025
Grand Ohio River Cruise
From $8,075
ON SALEFrom $8,075 $7,575
SOLD OUT
  • American Heritage | Paddlewheeler
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from Pittsburgh, PA to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Jun 19, 2026
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $0
SOLD OUT
  • American Melody | American Riverboat
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from St. Louis, MO to Pittsburgh, PA
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Aug 1, 2026
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $0
SOLD OUT
  • American Melody | American Riverboat
  • 15 Days / 14 Nights | 11 Ports of Call
  • One Way from Pittsburgh, PA to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Aug 22, 2026
Grand Ohio River Cruise
From $8,075
ON SALEFrom $8,075 $0
SOLD OUT
  • American Heritage | Paddlewheeler
  • 15 Days / 14 Nights | 11 Ports of Call
  • One Way from Pittsburgh, PA to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Jun 18, 2027
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $0
SOLD OUT
  • American Melody | American Riverboat
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from St. Louis, MO to Pittsburgh, PA
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Jul 23, 2027
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $0
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Aug 13, 2027
Grand Ohio River Cruise
From $9,240
ON SALEFrom $9,240 $0
SOLD OUT
  • American Melody | American Riverboat
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from Pittsburgh, PA to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing an Ohio River cruise between Pittsburgh and St. Louis, visiting Wheeling, Moundsville, Marietta, Maysville, Newport, Cincinnati, Louisville, Evansville, Henderson, Paducah, Cape Girardeau, and Kimmswick
Start Date: Aug 27, 2027
Grand Ohio River Cruise
From $8,075
ON SALEFrom $8,075 $0
SOLD OUT
  • American Heritage | Paddlewheeler
  • 16 Days / 15 Nights | 11 Ports of Call
  • One Way from Pittsburgh, PA to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
About American Riverboat | 180 Guests

The brand new American Riverboats have elevated the standard for riverboat cruising across the country. This new class of modern riverboats is the first of its kind in the U.S. and features contemporary styling, a grand multi-story atrium in the center of the ship, a variety of sizable lounges, and private balconies in each spacious stateroom.

What's included on our American Riverboats:

  • Inaugurated 2018-2023
  • Contemporary styling throughout
  • Multi-story glass atrium in center of the ship
  • Skywalk included on select ships (American Serenade, American Symphony, and American Melody)
  • Signature Sky Lounge with panoramic views
  • Expanded suites – the largest among our fleet
  • Private balconies on all staterooms
  • Sun deck
  • Outdoor cafĂ© dining option
  • Indoor fitness center
About Paddlewheeler | 150 Guests

These nostalgic ships of yesteryear offer a classic paddlewheeler experience with modern design features and amenities. Guests can enjoy large staterooms with private balconies and hotel-style bathroom, and a variety of unique lounges.

What's Included on our Traditional Paddlewheelers:

  • Inaugurated 2012-2016
  • Authentic paddlewheel experience
  • Signature Sky Lounge with panoramic views
  • Sun deck
  • Private balconies in most staterooms
  • Exercise equipment available
  • Breakfast room service

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