Dates & Fares for Upper Mississippi River Cruise

Return to Cruise Overview

9 Days - 8 Nights One Way 8 Ports

× Clear All Filters

70 results

We're sorry, your search did not produce any results. Please revise your cruise criteria and search again.

If you require assistance, please call us at 800-460-4518

Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Jun 13, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $0
SOLD OUT
  • American Melody | American Riverboat
  • 9 Days / 8 Nights | 8 Ports of Call
  • One Way from St. Paul, MN to St. Louis, MO
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Jul 4, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $5,135
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Jul 11, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $5,135
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Aug 1, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $5,135
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Aug 8, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $5,135
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Aug 15, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $5,135
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Aug 22, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $5,135
SOLD OUT
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Map showing a Mississippi River cruise between St. Louis and St. Paul, visiting Alton, Hannibal, Muscatine, Davenport, Dubuque, La Crosse, Winona, Red Wing, and Minneapolis
Start Date: Aug 29, 2025
Upper Mississippi River Cruise
From $5,635
ON SALEFrom $5,635 $0
SOLD OUT
  • American Melody | American Riverboat
  • 9 Days / 8 Nights | 8 Ports of Call
  • One Way from St. Louis, MO to St. Paul, MN
  • Complimentary Airfare Included
  • Complimentary Hotel Stay Included
More +
Questions? Contact a Dedicated Cruise Specialist
800-460-4518
Load More
About American Riverboat | 180 Guests

The brand new American Riverboats have elevated the standard for riverboat cruising across the country. This new class of modern riverboats is the first of its kind in the U.S. and features contemporary styling, a grand multi-story atrium in the center of the ship, a variety of sizable lounges, and private balconies in each spacious stateroom.

What's included on our American Riverboats:

  • Inaugurated 2018-2023
  • Contemporary styling throughout
  • Multi-story glass atrium in center of the ship
  • Skywalk included on select ships (American Serenade, American Symphony, and American Melody)
  • Signature Sky Lounge with panoramic views
  • Expanded suites – the largest among our fleet
  • Private balconies on all staterooms
  • Sun deck
  • Outdoor cafĂ© dining option
  • Indoor fitness center

Start This Reservation
Need Assistance? Need Help?
Call 800-460-4518