Embark upon a once-in-a-lifetime Mississippi River adventure with American Cruise Lines. Choose from our nine amazing itineraries that sail the legendary Mississippi, Ohio, and Cumberland Rivers, with cruises running from New Orleans to the Twin Cities.

Follow the footsteps of the epic Lewis and Clark Expedition as you cruise the legendary Columbia and Snake Rivers. Aboard the newest riverboats in the region, you will be amazed by the beautiful and ever-changing landscapes, including the Columbia River Gorge, Multnomah Falls and Mount St. Helens.

The islands and harbors of New England and Maine are among the most desired summer vacation retreats. From the quaint island villages of Nantucket and Martha's Vineyard, to the rugged beauty of the Maine coast, we have created captivating small ship cruise itineraries for the most discerning traveler.