Ohio River Cruise

Experience the picturesque waterways of the Mississippi and Ohio Rivers on this 11-day adventure. Your journey begins in "steel city," Pittsburgh, PA, and continues to the historic river port town of Cape Girardeau.

In Paducah, view the more than 50 life-sized panoramic murals that decorate the shoreline and paint a vivid picture of the city’s past. Visit the John James Audubon Museum in Henderson, featuring many original oil and watercolor paintings created by this famous artist.

While in Louisville, get a behind the scenes tour of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery. At the Underground Railroad Freedom Center in Cincinnati, learn about the sacrifices made so that the enslaved could escape to freedom.

Along the way, enjoy the idyllic countryside and native sounds of original bluegrass music.  

Ask about our Current Savings and our Complimentary Pre-cruise Packages which include a premium hotel stay and transportation to the ship. Click the Schedules & Rates tab for details.

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Cruise Itinerary

Day
Ports of Call
1
Pittsburgh, PA
2
Marietta, OH
3
Maysville, KY
4
Cincinnati, OH
5
Louisville, KY
6
Louisville, KY
7
Henderson, KY
8
Paducah, KY
9
Cape Girardeau, MO
10
St. Louis, MO
11
St. Louis, MO

Ohio River Cruise

Step back in time to the grand era of paddlewheels as we explore the heartland of America. While the churn of the paddlewheel blends with the sounds of the river, rediscover the America of the pioneers, boundless optimism, and unlimited possibilities.

Ports of Call

  • Pittsburgh, PA
  • Pittsburgh, PA
  • Marietta, OH
  • Maysville, KY
  • Cincinnati, OH
  • Louisville, KY
  • Louisville, KY
  • Henderson, KY
  • Paducah, KY
  • Cape Girardeau, MO
  • St. Louis, MO
  • St. Louis, MO
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Day by Day

Reverse itineraries available. Please contact your Cruise Specialist for your specific Day By Day agenda.

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Pre-Cruise
Pittsburgh, PA

Each Mississippi itinerary comes complete with a Complimentary Pre-Cruise Package, providing you with a seamless way to board the ship and explore the local area. Arrive the day before your scheduled cruise date and American Cruise Lines will handle the rest. The package includes a premium hotel stay, where you can enjoy the city at your leisure. On the morning of the cruise, meet in the hotel lobby after breakfast and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.

*Pre-Cruise Package is not available for reservations made within 30 days of cruise date.

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Day 1
Pittsburgh, PA

Begin your journey in the "steel city," Pittsburgh, PA. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce, making it a wealthy town in the 18th and 19th centuries.

*Note: River conditions can affect any cruise and the upper part of the Ohio River can be particularly sensitive to fluctuating conditions. In the event that the ship can’t dock in Pittsburgh, guests will be transported by bus from the hotel to the ship to begin their cruise.

For those cruises ending in Pittsburgh, guests will be transported from the ship to Pittsburgh to enjoy the city excursions.

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Pittsburgh Experience - Complimentary Excursion

Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce making it a wealthy town in the 18th and 19th centuries. Pass by the Heinz Stadium home to the NFL Pittsburgh Steelers and PNC Park, home to the MLB Pittsburgh Pirates.

*Only available on cruises ending in Pittsburgh.

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Senator John Heinz History Museum - Complimentary Excursion

Named after Republican Politician Senator John Heinz, this interactive museum is full of six floors worth of Western Pennsylvania history, highlighting the past 250 years. Exhibits include the life of Senator John Heinz, the history of Pittsburgh, professional sports memorabilia, and much more. This museum offers something for everyone.

*Only available on cruises ending in Pittsburgh.

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Day 2
Marietta, OH

The second-largest city in the Parkersburg-Marietta-Vienna Metropolitan area, Marietta was named in honor of Marie Antoinette. During the 18th and 19th-century, the town experienced economic prosperity, as its location on the Ohio River made it an attractive stop for commercial steamboats and travelers.

Small ship cruise on the Ohio River

Campus Martius Museum & Ohio River Museum - Complimentary Excursion

Tour two of Marietta’s greatest treasures: the Campus Martius Museum and the Ohio River Museum. The Campus Martius Museum features exhibits focusing on America’s migration out West and Marietta’s earliest native inhabitants. At the Ohio River Museum, discover the golden age of the steamboat and learn about the ecology of the Ohio River system 

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The Castle Historic House Museum - Complimentary Excursion

Tour this beautifully preserved, 1855 Gothic-Revival house which is on the National Register of Historic Places. The Castle was once home to some of Marietta's most prominent citizens and the site of many prestigious functions. Hear fascinating stories about its history and learn about of one of the oldest regions in the Northwest Territory.

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Day 3
Maysville, KY

Maysville, KY is a quaint town on the Ohio River with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original bluegrass country music.

Explore historic homes on our river cruises

Old Washington Tour - Complimentary Excursion

Step back in time while you tour the historic town of Old Washington, Kentucky. Starting at the 1790s Visitor Center, your costumed tour guide will lead you through this historic Kentucky village, taking you along flagstone sidewalks graced with authentic frontier log cabins and early 19th-century homes. This two-hour walking tour will include stops at the Simon Kenton Shrine, Albert Sidney Johnston House, and the Harriett Beecher Stowe Slavery to Freedom Museum.

Ohio River cruises

Maysville Highlights Tour - Complimentary Excursion

Enjoy the small town charm of historic Maysville, during this narrated tour. Begin at the Kentucky Gateway Museum Center, which brings the stories of explorers, artists, and movie stars to life through award-winning dioramas and its collection of historic artifacts. Next, visit the historic Russell Theater a true piece of the town’s history. The tour will conclude at the Cox Building which was built in 1886 and features Richardson Romanesque architecture. 

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Day 4
Cincinnati, OH

Enjoy a visit to Cincinnati, a vibrant city and cultural center which boasts two major sports franchises, as well as numerous theatres and museums. Explore its picturesque streets, abounding in eclectic architecture. 

Mississippi River Cruising

Cincinnati City Tour - Complimentary Excursion

Explore both sides of the river on this fantastic, all-encompassing tour. Highlights include the floodwall murals, downtown river district, St. Mary’s Cathedral Basilica of the Assumption, and Eden Park. Built in 1933, Krohn Conservatory lies in the heart of Eden Park. This art deco building is architecturally significant, but it is the contents inside the aluminum and glass walls that make it truly special, as it is home to more than 5,000 varieties of exotic, tropical, desert, and orchid plants from around the world.

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National Underground Railroad Freedom Center - Complimentary Excursion

The National Underground Railroad Freedom Center celebrates the brave men and women who came together to create a secret network through which the enslaved could escape to freedom. Their example of courage, cooperation, and perseverance, is relevant to this day, as we continue to deal with contemporary issues of equality and diversity. 

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Day 5
Louisville, KY

Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing.Discover why Louisville is often referred to as either the northernmost southern city or the southernmost northern city in the United States.

small ship cruising

Louisville Slugger Museum & Factory

Louisville Slugger is the maker of the world’s most popular bat. The company’s storied traditions and high standards for quality have produced some of the finest bats for amateurs and professionals alike. Take a guided tour of the facility and museum, learning first-hand their processes from forest-to-factory and the scientific principles used to fabricate the most important tool in “America’s Game.” Enjoy special seasonal exhibits and receive a free souvenir bat to commemorate your visit.

Small Ship Cruising

Jim Beam American Outpost

Bourbon enthusiasts will revel in a visit to the famous Jim Beam distillery. Celebrate “America’s First Family of Bourbon,” as you learn about their over 200 years of bourbon-making and view historic artifacts. Your private tour will include a visit to the home where three generations of Beam distillers lived. Step inside the Stillhouse Exhibit, which features an authentic 1800s copper still believed to be one of the oldest in America. Your tour will conclude in the rack house, where the bourbon is aged and the sampling begins. Visit the popular gift shop to purchase a variety of bourbons, bar ware, and other Jim Beam merchandise. 

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Day 6
Louisville, KY

Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing.Discover why Louisville is often referred to as either the northernmost southern city or the southernmost northern city in the United States.

small ship cruising

Kentucky Derby Museum & Horse Park - Complimentary Excursion

Get a behind-the-scenes tour of the Churchill Downs, the site of the famed Kentucky Derby. Here, you will have exclusive access to every facet of the race, from the Press Box and Jockey’s to Millionaire’s Row, the most coveted seats on race day. Visit the Kentucky Derby Museum to see actual Derby footage dating as far back as 1918.

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Day 7
Henderson, KY

You won’t miss the presence of the notable resident, John James Audubon, whose “Birds of America” paintings are recreated as bronze statues throughout Henderson. Named after President Washington’s home on the Potomac, this bucolic river town is steeped in fascinating lore. Let our expert guide lead you on a tour of our famous first President's historic home and grounds.

small ship cruising

Audubon Museum Tour

After docking in the tranquil port of Henderson, our morning will begin with a short narrated walk to the famous John James Audubon Museum.  Listed in the National Register of Historic Places, the museum features many original oil and watercolor paintings created by Audubon as well as many of his personal possessions. Your day will continue with the resident naturalist who will provide a narrated tour of the popular Nature Center, which was recently named one of the Top 25 Birdwatching Spots. At the conclusion of the tour, you will have free time for independent exploration.

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Day 8
Paducah, KY

Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library.

small ship cruising

Paducah City Tour & National Quilt Museum

Let our local guide take you through the quaint city of Paducah. This tour has been carefully divided into three distinct sections to make sure you experience all that Paducah has to offer. First, tour the downtown as our local expert guide points out the areas’ many historical sites. Then, take a leisurely stroll along the riverfront where you will witness more than 50 life-sized panoramic murals depicting elements of Paducah’s past. End the tour at the National Quilt Museum, the world's largest museum devoted to quilt and fiber art.

small ship cruising

River Discovery Center

Just a short distance from the ship’s docking location is the River Discovery Center, where guests learn about the Four Rivers region. Explore state-of-the-art interactive exhibits such as the working lock and dam model and the pilothouse simulator which allows you test your skills and captain your own riverboat!

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Day 9
Cape Girardeau, MO

Enjoy the charming features of this historic town that in the late 1800s was a French trading post and lively river port. Today, it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

small ship cruising

Trail of Tears State Park

The evening before arriving in Cape Girardeau, your onboard historian will paint a vivid picture of the Cherokee peoples' crossing of the Mississippi River to land in present-day Oklahoma. The forced march became known by the Cherokee people as the Trail of Tears due to its devastating effects. Memorializing this event is the Trail of Tears State Park. Led by our expert guide, explore the interpretive center, which houses a series of interpretive panels, paintings, maps, and other memorabilia, depicting the Cherokees’ tragic crossing of the Mississippi River.

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Cape Girardeau Experience - Complimentary Excursion

Join a local guide on a narrated tour of Cape Girardeau and stop at the Crisp Museum. A part of the River Campus of Southeast Missouri State University, the museum features fine art exhibitions, prehistoric Native American artifacts, one of the largest collections of ceramic conch shell effigies in North America, and interpretive regional history displays. Upon arrival, watch a wonderful introductory film, followed by a museum tour, where you can view a life-sized replica of a Native American dwelling.

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Day 10
St. Louis, MO

St. Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, and the Missouri History Museum. End your day at the Missouri Botanical Garden, one of the world’s most popular public gardens.

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Missouri History Museum

Enjoy a guided tour through two of the museum’s most popular exhibits; The 1904 World’s Fair: Looking Back at Looking Forward, an event that attracted over 200,000 visitors to the opening day and Route 66: Main Street through St. Louis, a roadway which played an important role in American History, not only in fact but in myth. Learn about the companies and tourist traps that travelers had to pass through.

*Note: This tour is only offered on cruises ending in St. Louis, MO.

american cruises

Discover St. Louis Tour - Complimentary Excursion

Enjoy a narrated tour of downtown St. Louis, the riverfront, Citygarden, and the historic neighborhoods of Soulard and Lafayette Square. Delight in a visit to St. Louis' 1,371 acre Forest Park, known as a natural oasis in an urban environment.

*Note: This tour is only offered on cruises ending in St. Louis, MO.

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Day 11
St. Louis, MO

Departure day. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.

Experiences

On this 8-day journey from St. Louis to Pittsburg, explore the America of yesteryear. The art, music, history, and natural beauty of the region is an all-encompassing experience.

Your Cruise Includes

Queen of the Mississippi

Built in 2015, Queen of the Mississippi offers an authentic experience with all the comforts of home. Guests can enjoy large staterooms with private balconies, hotel-style bathrooms, complimentary room service, WiFi, and more. Experience breathtaking scenery from the privacy of your stateroom as the Queen of the Mississippi makes its way down the legendary river. 


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Owner's Suite

Deckplan

At a generous up to 445 sq. ft., the Owner’s Suites of Queen of the Mississippi offer the finest accommodations with unsurpassed views of the Mississippi River. With a spacious seating area and full-size bathrooms, each suite is a private sanctuary where you can unwind after a day of exploration in the tasteful comfort of your surroundings. Each of these suites features large sliding glass doors leading out to a private balcony, where you can enjoy the ever-changing scenery. Every modern amenity is at your fingertips, along with a desk, and spacious seating area.

AAM (Private Balcony)

Deckplan

Located on the top deck, these spacious staterooms feature scenic views of the passing landscape. At 328 . ft., you will enjoy all of the modern comforts that are expected of a premium hotel. These staterooms also offer full-size bathrooms and a walk-out private balcony where the grandness of the Mississippi can be appreciated.

AAC (Private Balcony)

Deckplan

Our AAC staterooms are conveniently located on the fourth deck and at 304 sq. ft. offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular panoramic views of the Mississippi River and the surrounding landscape. 

AAL (Private Balcony)

Deckplan

AAL staterooms can be found on the third deck of the Queen of the Mississippi. Enjoy a luxurious 304 . ft. of living space that is equipped with plush seating, a full-size bathroom, and a private balcony with large sliding glass doors that offer great views of the Mississippi scenery. 

AAR (Private Balcony)

Deckplan

AAR staterooms can be found on the second deck of the Queen of the Mississippi. Enjoy a luxurious 304 sq. ft. of living space that is equipped with a full-size bathroom and a large private balcony with sliding glass doors.  

A

Deckplan

These 290 sq ft staterooms offer exceptional comfort and a relaxing living area. Featuring a large opening picture window, all are equipped with modern amenities, full-size bathrooms, and closet space.

Single (Private Balcony)

Deckplan

Perfect for the solo traveler, our Single staterooms offer all of the amenities you expect from a fine hotel. At 230 sq. ft., these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony.

Single

Deckplan

A comfortable getaway, our Single staterooms offer individuals a spacious room with convenient amenities. At 203 . ft., all have interior entrances and large viewing windows where the sights of the Mississippi can be enjoyed.

Queen of the Mississippi Deck Plan

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* Prices displayed are per person based on double occupancy.

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