Mississippi River Cruising Perfected

Cruise the legendary Mississippi River aboard the newest riverboats in the region and enjoy perfect comfort and modern amenities as you travel to each historic destination. Gliding past the rolling farmland on American Jazz (2020), American Harmony (2019), America (2016), and Queen of the Mississippi (2015) is a testament to the ingenuity of the pioneers who first traveled these waters. The fabric of the region is brought to life through our delicious regional cuisine, great on onboard music, and customized excursions to historical landmarks. Enjoy one of our themed cruises along the River, perfect for music aficionados, culinary connoisseurs and history enthusiasts.

What are Mississippi River Cruises?

Upper Mississippi River Cruises sail the area between St. Louis, Missouri and St. Paul, Minnesota.  Lower Mississippi River Cruises sail from Memphis, Tennessee and New Orleans, Louisiana. In addition to cruises directly on Mississippi River, there are also cruises that cruise its tributaries including the Ohio, and Tennessee Rivers.

Mississippi River Cruises

Complimentary Pre-Cruise Hotel

Pre-Cruise Hotel Package

Plus Save $400 when you reserve 9 months in advance
Call 800.460.4518 for additional details.

Videos

  • The Best Way to Experience the Lower Mississippi

    Join American Cruise Lines on an unforgettable journey along the Lower Mississippi River. Explore grand plantations, Civil War battlefields, and legendary cities, led by our engaging expert guides. Aboard the world’s finest paddlewheelers and modern riverboats, be treated to gracious accommodations, engaging enrichment programs, exquisite cuisine, and a level of personalized service unprecedented in river cruising.

  • The Best Way to Experience the Heartland

    The dramatic landscapes of the Upper Mississippi River have long inspired artists, writers, and steamboat passengers. Explore the area’s iconic landmarks, historic homes, and local museums, led by our expert guides. On board, be treated to enriching programs which complement the onshore excursions. After a day of discovery, relax on your private balcony and admire the picturesque scenery of America’s Heartland.

The American Cruise Lines Difference

Plantation Home
Historic Destinations
Lobster-tails, asparagus, and lemon
Delicious Cuisine
Housekeeping placing folded white towels and blue flowers on a white bed
Gracious Service
Trumpets
Nightly Entertainment