Mississippi River Cruises

From northern Minnesota to its mouth at the Gulf of Mexico, the Mississippi River offers a uniquely American cruise experience. With more than 50 years’ experience and a fleet of 5 ships ranging from steamboat-style paddlewheelers to the newest modern luxury riverboats, American Cruise Lines is the leading operator of Mississippi River cruises. 

Our 12 unique itineraries provide guests more ways to explore the Mississippi than any other cruise line, while the sophisticated comfort of our modern riverboats offers the largest staterooms, private balconies, and complimentary excursions at every port.

Receive Free Airfare & Savings up to $1,000* on select Lower Mississippi River Cruises. Expires May 31, 2024.

Filter By:
Filter By:
× Clear Selections
× Clear Selections
We’re sorry, your search did not produce any results.

Historic Mississippi River Cruise

New Orleans, LA to New Orleans, LA

Free Airfare* Plus Save up to $1,000
8 Days / 7 Nights
From
$3,475
$3,075

Lower Mississippi River Cruise

Memphis, TN to New Orleans, LA

Free Airfare* Plus Save up to $1,500
9 Days / 8 Nights
From
$4,220
$3,720

Upper Mississippi River Cruise

St. Louis, MO to St. Paul, MN

Save up to $1,200
9 Days / 8 Nights
From
$4,530

Music Cities Cruise

Memphis, TN to Nashville, TN

Free Airfare* Plus Save up to $1,000
9 Days / 8 Nights
From
$4,220
$3,720

Tennessee Rivers Cruise

Chattanooga, TN to Nashville, TN

Free Airfare* Plus Save up to $1,200
9 Days / 8 Nights
From
$4,220
$3,720

Mississippi Explorers Cruise

New Orleans, LA to Memphis, TN

12 Days / 11 Nights
From
$5,900

Ohio River Cruise

Louisville, KY to Pittsburgh, PA

Free Airfare* Plus Save up to $1,200
9 Days / 8 Nights
From
$4,530
$3,930

Great Smoky Mountains National Park

Knoxville, TN to Nashville, TN

12 Days / 11 Nights
From
$7,030

Complete Mississippi River Cruise

New Orleans, LA to St. Paul, MN

Free Airfare* Plus Save up to $4,000
23 Days / 22 Nights
From
$15,640
$13,640

Grand Heartland Cruise

St. Paul, MN to New Orleans, LA

Save up to $1,200
16 Days / 15 Nights
From
$10,255
$9,655

Mississippi River Gateway Cruise

New Orleans, LA to St. Louis, MO

Save up to $1,000
12 Days / 11 Nights
From
$6,245
$5,745

Grand Ohio River Cruise

Pittsburgh, PA to St. Louis, MO

Free Airfare* Plus Save up to $2,000
16 Days / 15 Nights
From
$7,545
$6,545

*Offer Valid Only on New Bookings on Select Dates

America's Most Awarded Mississippi River Cruise Line

Mississippi River Cruising

Mississippi River Cruising

Featured Ports

New Orleans, LA

Vicksburg, MS

Memphis, TN

Hannibal, MO

What Sets Us Apart

Made For You: A Personalized Mississippi River Cruise

As you cruise the legendary Mississippi River, our dedicated crew will treat you with gracious hospitality and the utmost care. Enjoy the intimacy and comfort of small-ship cruising, where our crew will quickly learn your name and preferences as you travel with us. Our onboard experts don’t just lecture, they spend time with guests aboard and on shore, giving real insight and depth to each destination visited. Many even dine with our guests.

Unique Excursions, Local Guides

From New Orleans, LA to St. Paul, MN, enjoy well-customized excursions, led by engaging local guides who live and work in these great port cities of America’s Heartland. Get a backstage pass to Elvis’ Graceland and the legendary Sun Studio in Memphis. Explore the boyhood town of Mark Twain in Hannibal and be treated to a live show at the Grand Old Opry in Nashville.

Spacious Accommodations

Whether on board a modern riverboat or newly refurbished paddlewheeler, American Cruise Lines is proud to offer the largest staterooms in the industry, with full-size bathrooms, and private balconies offering the perfect vantage point from which to admire the scenic rolling river views. Guests can also look forward to discovering spacious lounges and quiet nooks to gather with fellow travelers.

Onboard Experience

Travel to the birthplace of jazz, blues, and rock–n-roll as our talented onboard musicians entertain you with songs born along the river. Dine on the finest Cajun and Creole and mouth-watering Memphis BBQ prepared by our team of master chefs. Enjoy a complimentary cocktail hour every evening, a time when you can share the day’s adventures with like-minded travelers, while enjoying a refreshing mint julep.