Mississippi River Cruises

Embark upon a once-in-a-lifetime Mississippi River adventure with American Cruise Lines. Choose from our nine amazing itineraries that sail the legendary Mississippi, Ohio, and Cumberland Rivers, with cruises running from New Orleans to the Twin Cities. Explore Vicksburg and other Civil War battlefields as well as the historic Mississippi Delta, or steep yourself in the heart of American music in Memphis and Nashville. Step inside the storybook town of Hannibal, MO, where Mark Twain created the characters of Tom Sawyer and Huck Finn. Join us aboard our modern fleet traveling the upper and lower Mississippi River, including brand new contemporary riverboats and traditional paddlewheelers, and enjoy guided excursions to famous port cities, locally inspired cuisine, and a full array of small ship amenities.

New Orleans - New Orleans

New Orleans, LA to New Orleans, LA

8 Days / 7 Nights

Visit Oak Alley Plantation, Houmas House, and Natchez, and more as you enjoy this round-trip river cruise from New Orleans.

Lower Mississippi River Cruise

Memphis, TN to New Orleans, LA

8 Days / 7 Nights

Be treated to southern hospitality and vibrant onboard entertainment on your riverboat adventure between New Orleans and Memphis. Listen to the sounds of Graceland and learn about Civil War history in Vicksburg. Experience the culture of Louisiana, Tennessee, and Mississippi.

Upper Mississippi River Cruise

St. Louis, MO/Alton, IL to St. Paul, MN

8 Days / 7 Nights

Surround yourself with the river landscapes that inspired Mark Twain - from St. Louis to Hannibal to St. Paul. Explore the scenic bluffs, gardens, and homes that define the region.

Complete Mississippi River Cruise

New Orleans, LA to St. Paul, MN

22 Days / 21 Nights

The ultimate Missisippi cruise - traversing the entire length of the river - stopping at all of the most iconic ports in the region, including New Orleans, Memphis, Hannibal, Winona, and more.

Highlights of the Mississippi River

New Orleans, LA to New Orleans, LA

5 Days / 4 Nights

Experience 'The Big Easy' like never before. From there, make your way to classic southern spots such as Houmas House, Oak Alley, and Baton Rouge.

Ohio River Cruise

Pittsburgh, PA to St. Louis, MO

11 Days / 10 Nights

Journey through America's Heartland via the Ohio River. Sip Mint Juleps in Kentucky, sight see in "Steel City" Pittsburgh, and enjoy a glass of sweet tea on your private balcony.

The Tennessee Rivers Cruise

Chattanooga, TN to Nashville, TN

Tennessee Rivers Cruise
8 Days / 7 Nights

Cruise the Tennessee Valley aboard our newest modern riverboat. You'll make stops in Nashville, TN, Chattanooga, TN, Paducah, KY, and more. This journey includes the sounds of iconic music, the sights of Civil War history, and the smells of whiskey and bourbon.

Grand Heartland Cruise

St. Paul, MN to New Orleans, LA

15 Days / 14 Nights

Witness the dramatic landscapes of the Upper Mississippi River and treat yourself to Blues and BBQ. Guests can choose their perfect itinerary whether aboard a modern riverboat or authentic paddlewheeler.

Music Cities Cruise

Memphis, TN to Nashville, TN

8 Days / 7 Nights

Tap your feet aboard American Jazz and sail through the musical meccas of the country. Our soulful Memphis to Nashville river cruise combines history, music, and vibrant culture.

Mississippi River Gateway Cruise

New Orleans, LA to St. Louis, MO

11 Days / 10 Nights

Begin in the French Quarter of New Orleans and continue to Baton Rouge and Natchez. Explore the "Gateway to the West" via St. Louis, rock 'n' roll to Graceland, view Civil War landmarks, and stroll through the museums and art galleries of Paducah.

Our Mississippi River Fleet


Featured Ports

New Orleans







What Sets Us Apart

Made For You: A Personalized Mississippi River Voyage

Made For You: A Personalized Mississippi River Cruise

As you cruise the legendary Mississippi River, our dedicated crew will treat you with gracious hospitality and the utmost care. Enjoy the intimacy and comfort of small-ship cruising, where our crew will quickly learn your name and preferences as you travel with us. Our onboard experts don’t just lecture, they spend time with guests aboard and on shore, giving real insight and depth to each destination visited. Many even dine with our guests.

Unique Excursions, Local Guides

Unique Excursions, Local Guides

From New Orleans, LA to St. Paul, MN, enjoy well-customized excursions, led by engaging local guides who live and work in these great port cities of America’s Heartland. Get a backstage pass to Elvis’ Graceland and the legendary Sun Studio in Memphis. Explore the boyhood town of Mark Twain in Hannibal and be treated to a live show at the Grand Old Opry in Nashville.

Spacious Accommodations

Spacious Accommodations

Whether on board a modern riverboat or newly refurbished paddlewheeler, American Cruise Lines is proud to offer the largest staterooms in the industry, with full-size bathrooms, and private balconies offering the perfect vantage point from which to admire the scenic rolling river views. Guests can also look forward to discovering spacious lounges and quiet nooks to gather with fellow travelers.

Onboard Experience

Onboard Experience

Travel to the birthplace of jazz, blues, and rock–n-roll as our talented onboard musicians entertain you with songs born along the river. Dine on the finest Cajun and Creole and mouth-watering Memphis BBQ prepared by our team of master chefs. Enjoy a complimentary cocktail hour every evening, a time when you can share the day’s adventures with like-minded travelers, while enjoying a refreshing mint julip.