Mississippi River Cruises
Cruise the legendary Mississippi River aboard the newest riverboats in the region and enjoy perfect comfort and modern amenities as you travel to each historical destination. The fabric of the region is brought to life through our delicious regional cuisine, live onboard music, and customized excursions. Choose from nine amazing Mississippi River itineraries including the Lower Mississippi River Cruise traveling from festive New Orleans to soulful Memphis, the Upper Mississippi River Cruise which explores from fascinating St. Louis to welcoming St. Paul, MN, or the Complete Mississippi River Cruise which traverses the entire length of this amazing and historic river.
New Orleans - New Orleans
New Orleans, LA to New Orleans, LA
Visit Oak Alley Plantation, Houmas House, and Natchez, and more as you enjoy this round-trip river cruise from New Orleans.
View Map
New Orleans - New Orleans
New Orleans, LA to New Orleans, LA
- Pre-Cruise Package and Complimentary Hotel Stay
- Day 1 New Orleans, LA
- Day 2 Oak Alley, LA
- Day 3 Natchez, MS
- Day 4 Vicksburg, MS
- Day 5 St. Francisville, LA
- Day 6 Baton Rouge, LA
- Day 7 Houmas House, LA
- Day 8 New Orleans, LA
Lower Mississippi River Cruise
Memphis, TN to New Orleans, LA
Be treated to southern hospitality and vibrant onboard entertainment on your riverboat adventure between New Orleans and Memphis. Listen to the sounds of Graceland and learn about Civil War history in Vicksburg. Experience the culture of Louisiana, Tennessee, and Mississippi.
Lower Mississippi River Cruise
Memphis, TN to New Orleans, LA
- Pre-Cruise Packages and Complimentary Hotel Stays
- Day 1 Memphis, TN
- Day 2 Day of River Cruising
- Day 3 Vicksburg, MS
- Day 4 Natchez, MS
- Day 5 St. Francisville, LA
- Day 6 Baton Rouge, LA
- Day 7 Houmas House, LA
- Day 8 New Orleans, LA
Upper Mississippi River Cruise
St. Louis, MO/Alton, IL to St. Paul, MN
Surround yourself with the river landscapes that inspired Mark Twain - from St. Louis to Hannibal to St. Paul. Explore the scenic bluffs, gardens, and homes that define the region.
Upper Mississippi River Cruise
St. Louis, MO/Alton, IL to St. Paul, MN
- Pre-Cruise Packages and Complimentary Hotel Stays
- Day 1 St. Louis, MO/Alton, IL
- Day 2 Hannibal, MO
- Day 3 Fort Madison, IA
- Day 4 Davenport, IA
- Day 5 Dubuque, IA
- Day 6 Winona, MN
- Day 7 Red Wing, MN
- Day 8 St. Paul, MN
Complete Mississippi River Cruise
New Orleans, LA to St. Paul, MN
The ultimate Missisippi cruise - traversing the entire length of the river - stopping at all of the most iconic ports in the region, including New Orleans, Memphis, Hannibal, Winona, and more.
Complete Mississippi River Cruise
New Orleans, LA to St. Paul, MN
- Pre-Cruise Package and Complimentary Hotel Stay
- Day 1 New Orleans, LA
- Day 2 Oak Alley, LA
- Day 3 Houmas House, LA
- Day 4 Baton Rouge, LA
- Day 5 St. Francisville, LA
- Day 6 Natchez, MS
- Day 7 Vicksburg, MS
- Day 8 Greenville, MS
- Day 9 Memphis, TN
- Day 10 New Madrid, MO
- Day 11 Cape Girardeau, MO
- Day 12 Chester, IL
- Day 13 St. Louis, MO
- Day 14 Day of River Cruising
- Day 15 Hannibal, MO
- Day 16 Fort Madison, IA
- Day 17 Davenport, IA
- Day 18 Dubuque, IA
- Day 19 Day of River Cruising
- Day 20 Winona, MN
- Day 21 Red Wing, MN
- Day 22 St. Paul, MN
Highlights of the Mississippi River
New Orleans, LA to New Orleans, LA
Experience 'The Big Easy' like never before. From there, make your way to classic southern spots such as Houmas House, Oak Alley, and Baton Rouge.
Highlights of the Mississippi River
New Orleans, LA to New Orleans, LA
- Pre-Cruise Package and Complimentary Hotel Stay
- Day 1 New Orleans, LA
- Day 2 Houmas House, LA
- Day 3 Baton Rouge, LA
- Day 4 Oak Alley, LA
- Day 5 New Orleans, LA
Ohio River Cruise
Pittsburgh, PA to St. Louis, MO
Journey through America's Heartland via the Ohio River. Sip Mint Juleps in Kentucky, sight see in "Steel City" Pittsburgh, and enjoy a glass of sweet tea on your private balcony.
Ohio River Cruise
Pittsburgh, PA to St. Louis, MO
- Pre-Cruise Packages and Complimentary Hotel Stays
- Day 1 Pittsburgh, PA
- Day 2 Marietta, OH
- Day 3 Maysville, KY
- Day 4 Cincinnati, OH
- Day 5 Louisville, KY
- Day 6 Louisville, KY
- Day 7 Henderson, KY
- Day 8 Paducah, KY
- Day 9 Cape Girardeau, MO
- Day 10 St. Louis, MO
- Day 11 St. Louis, MO
Grand Heartland Cruise
St. Paul, MN to New Orleans, LA
Witness the dramatic landscapes of the Upper Mississippi River and treat yourself to Blues and BBQ. Guests can choose their perfect itinerary whether aboard a modern riverboat or authentic paddlewheeler.
Grand Heartland Cruise
St. Paul, MN to New Orleans, LA
- Pre-Cruise Complimentary Hotel Stay
- Day 1 St. Paul, MN
- Day 2 Winona, MN
- Day 3 Dubuque, IA
- Day 4 Davenport, IA
- Day 5 Fort Madison, IA
- Day 6 Hannibal, MO
- Day 7 St. Louis, MO
- Day 8 St. Louis, MO
- Day 9 Day of River Cruising
- Day 10 Memphis, TN
- Day 11 Greenville, MS
- Day 12 Vicksburg, MS
- Day 13 Natchez, MS
- Day 14 Baton Rouge, LA
- Day 15 New Orleans, LA
Music Cities Cruise
Memphis, TN to Nashville, TN
Tap your feet aboard American Jazz and sail through the musical meccas of the country. Our soulful Memphis to Nashville river cruise combines history, music, and vibrant culture.
Music Cities Cruise
Memphis, TN to Nashville, TN
- Pre-Cruise Packages and Complimentary Hotel Stays
- Day 1 Memphis, TN
- Day 2 Cruising the Mississippi and Ohio River
- Day 3 Paducah, KY
- Day 4 Cruising Lake Barkley and the Cumberland River
- Day 5 Dover, TN
- Day 6 Clarksville, TN
- Day 7 Nashville, TN
- Day 8 Nashville, TN
Mississippi River Gateway Cruise
New Orleans, LA to St. Louis, MO
Begin in the French Quarter of New Orleans and continue to Baton Rouge and Natchez. Explore the "Gateway to the West" via St. Louis, rock 'n' roll to Graceland, view Civil War landmarks, and stroll through the museums and art galleries of Paducah.
Mississippi River Gateway Cruise
New Orleans, LA to St. Louis, MO
- Pre-Cruise Packages and Complimentary Hotel Stays
- Day 1 New Orleans, LA
- Day 2 Baton Rouge, LA
- Day 3 Natchez, MS
- Day 4 Vicksburg, MS
- Day 5 Day of River Cruising
- Day 6 Memphis, TN
- Day 7 New Madrid, MO
- Day 8 Paducah, KY
- Day 9 Day of River Cruising
- Day 10 St. Louis, MO
- Day 11 St. Louis, MO
Our Mississippi River Fleet
Testimonials
Lower Mississippi
“This is the way to see America. A wonderful experience!”
– Donna F. - Bradenton, FL
Lower Mississippi
“The overall cleanliness of the ship was very welcome and impressive. The single thing we enjoyed the most was the quality of the food and the service that came with it. The cuisine was perfectly tailored to exhibit the Southern experience.”
– Robert J. - New Port Richey, FL
Lower Mississippi
“The total crew was excellent. We could not have had a more enjoyable and memorable experience. Starting and ending each day on our balcony enjoying the River was wonderful. Also didn't listen to or care about the daily news dribble. Our expectations were exceeded. Could not expect more than that. We will be back.”
– Robert C. - Ocala, FL
Lower Mississippi
“Being a history buff, I enjoyed learning about the history and lore of the Mississippi river and especially enjoyed Vicksburg and the military park tour.”
– Marcel L. - Southington, CT
New Orleans Round-Trip
“We enjoyed everything! It was all new to us and exceeded our expectations. The views, the side trips, the wonderful music, the great staff and crew, the incredible food—what’s not to love? Stay the course. You’ve got this. We will be back for sure, and you’ve set the bar very, very high with this first cruise. It was truly a wonderful time for us.”
– Thomas H. - Whitehouse, OH
Highlights of the Mississippi
“This cruise was my retirement gift to myself. The crew put chocolates in my room and a nice card congratulating me. I was surprised how wonderful everything was. This was the best trip I have ever been on. Thank you.”
– Bonnie P. - Wyandotte, MI
Highlights of the Mississippi
“Everything was wonderful. I cannot remember having such a great time. The entire staff was great and so accommodating. I loved this trip. I have been on cruises on big ships and there is no comparison. It was so much nicer on a smaller boat. We had the chance to meet and probably had a meal, a drink or excursion with almost everyone on board.”
– Cindy E. - Frederick, MD
Upper Mississippi
“I really appreciated how organized everything is. The flow of the tours, motor coach pick up and return, meal time and cocktail hour. The staff worked well to make the passengers not have to worry about anything except enjoying the experience. Loved all of the food. Wonderful selections at each meal!”
– Melanie S. - Salem, OR
Upper Mississippi
“The entire cruise was excellent: the accommodations, food, service and the scenery was spectacular! Loved the excursions and learned so much about small towns we had never visited before. Absolutely loved having McAvoy Layne on the cruise as Mark Twain. He was excellent and made the cruise even more special with his performance! Also loved the way he stayed in character even at dinner.”
– Thomas S. - Tarzana, CA
Upper Mississippi
“I enjoyed the luxury of being on the boat, watching the world go by quietly, and being pampered at every turn. I loved being able to pick and choose whatever I wished to do. Cruising the rivers was a complete joy. Our entertainment was exceptionally superb, as well. It was educational, historical, and entertaining!”
– Audrey I. - Inverness, IL
Upper Mississippi
“I loved the fact that there many things to do on the cruise, but absolutely no pressure to do any of them. We spent most of our time on our balcony, reading and watching the world go by. We had breakfast on the balcony every day and it was absolutely fantastic. The food was amazing, the service was incredible, and we are telling everyone about the wonderful time we had.”
– Richard M. - Savage, MN
Upper Mississippi
“I enjoyed the simple pleasure of cruising down the Mississippi. Just a big thank you for a wonderful cruise - the dream of a lifetime for me.”
– Georgene S. - Saint Louis, MO
Complete Mississippi
“A big thank you to American Cruise Line for making my father’s lifelong dream of sailing the Mississippi come true. He is 82 and had the time of his life!”
– William P. - Santa Clara, CA
Complete Mississippi
“Enjoyed cruising the Mississippi at a slow pace with beautiful views of the river; it all was so peaceful. It was so nice each day to be greeted by the staff with friendly smiles and willingness to be of help. The entertainment was some of the best ever of any cruise we've been on.”
– Ernest S. - Orting, WA
Grand Heartland
“Loved everything, but especially the friendliness of the staff, the small ship atmosphere, and the feeling of traveling with ‘family’.”
– Jeanne D. - San Clemente, CA
Mississippi Gateway
“I loved the small intimate atmosphere of the cruise. The relaxation of river cruising was amazing. Sitting on top of the boat at sunset, all by ourselves, was heaven on earth.”
– Susan C. - Davis, CA
Ohio River
“The boat was lovely and just the right size. The staff was excellent, pleasant and accommodating. The food was outstanding and the alcohol was plentiful and of high quality. The Riverlorians were knowledgeable charming. The entertainment was also great and the onboard activities were varied and enjoyable.”
– Heather O. - Green Valley, AZ
Featured Ports
What sets us apart
Personalized Hospitality
Attentive and gracious service
World Class Cuisine
Sourced by our master chefs
An American Experience
American-made, crew and destinations
Daily Onboard Entertainment
Musicians, historians and naturalists
Spacious Accommodations
The largest staterooms of any cruise ship
Complimentary & Inclusive
Cocktails, pre-cruise stay, excursions
Private Balconies
Unobstructed views, breathtaking scenery
