Find a Southeast US Cruise

European explorers found sanctuary in the bountiful lands of the Southeast centuries ago. Now, these tranquil waterways allow American Cruise Lines to provide guests with an exploration of history and natural beauty. Discover Southern charm as we cruise the Intracoastal Waterway or the early American ideal on our Chesapeake Bay Cruise. Our southern U.S. river cruises bring guests to unique, historic, and bucket-list destinations such as Tangier Island, Charleston, SC, Cambridge, MD, Washington D.C., Baltimore, and St. Augustine, FL.

Historic South and Golden Isles Cruise

Charleston, SC to Amelia Island, FL

8 Days / 7 Nights

On this Golden Isles river cruise from Charleston, through the Intracoastal Waterway, to Amelia Island you'll see the extravagant homes of Jekyll Island, stroll through the cobblestone streets of Savannah, GA, and discover dolphins on Hilton Head Island.

American Revolution Cruise

Baltimore, MD to Baltimore, MD

11 Days / 10 Nights

History buffs will revel in this 11-day Baltimore round trip cruise. Guests explore the cities and towns that shaped our country, including Washington D.C., Colonial Williamsburg, and Jamestown.

Great Rivers of Florida Cruise

Jacksonville, FL to Jacksonville, FL

8 Days / 7 Nights

This Florida 8-day Amelia Island round trip cruise features fascinating stops such as Green Cove Springs, St. Augustine, and Palatka.

Chesapeake Bay Cruise

Baltimore, MD to Baltimore, MD

8 Days / 7 Nights

This 7-day riverboat cruise takes guests to the "Crab Capital of the World," visits the U.S. Naval Academy in Annapolis, and many other historic ports, including Cambridge, MD, and Williamsburg, VA, that define our Chesapeake Bay cruises.

East Coast Inland Passage Cruise

Baltimore, MD to Amelia Island, FL

15 Days / 14 Nights

Guests will rediscover America on this captivating Baltimore, MD, to Amelia Island, FL, east coast cruise. From Kitty Hawk, NC, where the Wright Brothers took flight, to Charleston, SC, Hilton Head, SC, and St. Simons Island, GA - guests will revel in the charm of the Southeast.

Our Southeast Fleet


Featured Ports

Savannah, GA


Norfolk, VA


Charleston, SC


Baltimore, MD

What Sets Us Apart

Our Ships

Our Ships

American Cruise Lines' modern ships are a testament to premier nautical engineering, luxurious comfort, and the river cruising convenience. Our fleet of American riverboats, paddlewheelers, and small cruise ships offer the latest amenities, state-of-the-art navigation, and safety equipment.

Personalized Hospitality

Personalized Hospitality

We emulate the southern charm of this region on all of our cruises with our exceptional personalized service and hospitality. As you cruise in perfect comfort to ports like Charleston, SC, and Savannah, GA, enjoy spacious amenities, a private balcony, and an intimate oasis aboard our fleet of award-winning small ships.


World Class Cuisine

You will experience an authentic crab fest in Baltimore and delicious oysters in Charleston, but you will also taste exquisite cuisine onboard our ships. Our team of award-winning chefs locally sources ingredients with food that brings every region to life.

Daily Onboard Entertainment

Musicians, historians, and naturalists join every cruise, creating an entertaining onboard experience. Our cruises in this region focus heavily on southern history and culture, where even the most self-proclaimed history buffs will learn something new.