Find a Southeast U.S. Cruise

European explorers found sanctuary in the bountiful lands of the Southeast centuries ago. Now, these tranquil waterways allow American Cruise Lines to provide guests with an exploration of history and natural beauty. Discover Southern charm as we cruise the Intracoastal Waterway or the early American ideal on our Chesapeake Bay Cruise. Our southern U.S. river cruises bring guests to unique, historic, and bucket-list destinations such as Tangier Island, Charleston, SC, Cambridge, MD, Washington D.C., Baltimore, and St. Augustine, FL.

For a limited time, save up to $2,000 on select American Revolution Cruises and receive Free Airfare.*

Historic South & Golden Isles Cruise

Charleston, SC to Amelia Island, FL

Free Airfare* Plus Save up to $2,000
8 Days / 7 Nights
From
$4,610
$4,210

American Revolution Cruise

Washington, DC to Washington, DC

Free Airfare* Plus Save up to $2,000
11 Days / 10 Nights
From
$6,580
$5,580

Chesapeake Bay Cruise

Baltimore, MD to Baltimore, MD

Save up to $1,000
8 Days / 7 Nights
From
$4,610
$4,110

Great Rivers of Florida Cruise

Jacksonville, FL to Jacksonville, FL

Free Airfare* Plus Save up to $1,000
8 Days / 7 Nights
From
$5,270
$4,770

East Coast Inland Passage Cruise

Baltimore, MD to Amelia Island, FL

Free Airfare* Plus Save up to $1,500
15 Days / 14 Nights
From
$8,670
$8,070

Florida Gulf Coast & Keys Cruise

St Petersburg, FL to St Petersburg, FL

Free Airfare* Plus Save up to $1,200
8 Days / 7 Nights
From
$5,990
$5,490

Grand Florida Coast & Keys Cruise

St Petersburg, FL to Jacksonville/Amelia Island, FL

15 Days / 14 Nights
From
$11,570

Holidays in the Southeast

Charleston, SC to Amelia Island, FL

Save up to $1,000
8 Days / 7 Nights
From
$5,270
$4,770

*Offer Valid Only on New Bookings on Select Dates

Featured Ports

Savannah, GA

Norfolk, VA

Charleston, SC

Baltimore, MD

What Sets Us Apart

Our Ships

American Cruise Lines' modern ships are a testament to premier nautical engineering, luxurious comfort, and the river cruising convenience. Our fleet of American riverboats, paddlewheelers, and small cruise ships offer the latest amenities, state-of-the-art navigation, and safety equipment.

Personalized Hospitality

We emulate the southern charm of this region on all of our cruises with our exceptional personalized service and hospitality. As you cruise in perfect comfort to ports like Charleston, SC, and Savannah, GA, enjoy spacious amenities, a private balcony, and an intimate oasis aboard our fleet of award-winning small ships.

World Class Cuisine

You will experience an authentic crab fest in Baltimore and delicious oysters in Charleston, but you will also taste exquisite cuisine onboard our ships. Our team of award-winning chefs locally sources ingredients with food that brings every region to life.

Daily Onboard Entertainment

Musicians, historians, and naturalists join every cruise, creating an entertaining onboard experience. Our cruises in this region focus heavily on southern history and culture, where even the most self-proclaimed history buffs will learn something new.