Southeast U.S. & Intracoastal Waterway Cruises
Southeast Sea Islands Cruise
Charleston, SC to Amelia Island, FL
Florida Gulf Coast & Keys Cruise
St Petersburg, FL to St Petersburg, FL
Great Rivers of Florida Cruise
Jacksonville, FL to Jacksonville, FL
Gulf Coast Cruise
New Orleans, LA to Pensacola, FL
Grand Florida Coast & Keys Cruise
St Petersburg, FL to Amelia Island, FL
*Offer Valid Only on New Bookings on Select Dates
Where Our Southeast U.S. Cruises Travel
Our Southeast U.S. cruises explore some of the most scenic and historically significant waterways in the country. Sail through the Chesapeake Bay, cruise the protected Intracoastal Waterway, and experience the vibrant coastal cities of the Southeast. Popular routes include journeys between Charleston and Amelia Island, Florida Gulf Coast itineraries, and cruises visiting historic ports along the Mid-Atlantic and southern East Coast.
Intracoastal Waterway
Cruise along the Intracoastal Waterway, a protected network of rivers, bays, and canals that winds past quiet marshlands, charming coastal towns, and scenic waterfront homes. Along the way, watch for coastal birds like herons, egrets, and ospreys, as well as dolphins and other native wildlife that thrive in these sheltered waterways. This smooth, East Coast inland passage is a relaxing way to experience the natural beauty of the Southeast.
Everglades & 10,000 Islands
Explore the beauty of the Florida Everglades and the 10,000 Islands, a remote maze of mangroves, waterways, and untouched wilderness. Aboard a covered pontoon, navigate the serene Faka Union Canal and coastal labyrinth while watching for dolphins, manatees, alligators, and native birds. Along the way, local guides share fascinating insights into the region’s ecology, wildlife, and history, bringing this remarkable ecosystem to life.
Dry Tortugas
Seventy miles west of Key West lies Dry Tortugas National Park, one of North America’s most remote national parks. Surrounded by the Gulf, it is renowned for pristine beauty, abundant marine life, and pirate legends. At its heart stands Fort Jefferson, the Western Hemisphere’s largest brick masonry structure. Arrive by scenic seaplane over turquoise waters, then explore the fort, relax on tranquil beaches, or snorkel vibrant coral reefs.
Colonial Williamsburg
Step back in time in Colonial Williamsburg, the world’s largest living history museum. Stroll through restored streets, meet costumed interpreters, and experience daily life in 18th-century America. As Virginia’s capital, Williamsburg was a center of revolutionary activity, where colonial leaders debated independence, challenged British authority, and gathered at sites like the Raleigh Tavern in the years leading up to the Revolutionary War.
Featured Ports on Our Southeast U.S. Cruises
Key West, FL
As the southernmost point in the continental U.S., it’s no wonder Key West is an absolute paradise. Once a haven for pirates, it quickly became one of the wealthiest cities per capita in America due to its lucrative salvage industry. Today, its colorful streets, Hemingway’s former home, and century-old bars capture the rebellious, free-spirited charm that has attracted artists, writers, and everyone in between for generations.
Savannah, GA
Steeped in Southern charm and rich history, Savannah welcomes visitors with moss-draped oak trees, elegant squares, and beautifully preserved architecture. Stroll along the lively River Street waterfront, explore historic landmarks, or savor the city's renowned cuisine while experiencing one of the South's most beloved destinations.
Charleston, SC
Charleston’s cobblestone streets and colorful homes transport you back to the past. As one of America’s oldest cities, its history is filled with tales of colonial grandeur, Revolutionary battles, and Civil War turmoil. Jasmine and other flora are found throughout the historic districts, decorating centuries-old churches and preserved mansions standing as timeless reminders of its historical impact.
Baltimore, MD
Known as the birthplace of the national anthem, the city’s history is tightly woven with American identity. Its Inner Harbor is surrounded by historic sites like Fort McHenry, where “The Star-Spangled Banner” was penned, and neighborhoods like Fell’s Point, filled with 18th-century rowhouses that echo the city’s seafaring roots.
What Sets Us Apart
Discover the heart and soul of the South through its legendary hospitality, rich history, and breathtaking landscapes. Explore inviting coastal towns, savor authentic regional cuisine, and uncover fascinating stories from local experts. Enjoy an unrivaled level of personalized service and the most comfortable accommodations, as you experience the traditions and timeless beauty that define the Southeast.
Southeast Cruises FAQs
What should I pack for a Southeast U.S. cruise?
Packing for an Southeast U.S. cruise will be dependent on the season. If cruising the more southern East Coast during warmer months, it's important to bring lightweight clothing, sun protection, and light layers. If you're cruising during the colder months, make sure to pack layers to adjust to the changing temperature. No matter when you cruise, it's important to pack comfortable shoes and windbreaker to ensure you're ready for all weather.
What is the best time of year to cruise the Southeast U.S.?
There are three key seasons to cruising the southern U.S. East Coast: spring, fall, and winter. Springtime is great for mild weather, blooming flowers, and lighter crowds. Fall is the perfect time to see the magnificent leaves turn without the cold. Winter cruises offer a warm escape, festive holiday cheer, and serene coastal landscapes.
Where do American Cruise Lines cruises leave from in the Mid-Atlantic and on the southern East Coast?
Our Mid-Atlantic and Southeast U.S. itineraries leave from Philadelphia, PA; Washington, D.C.; Baltimore, MD; Charleston, SC; Amelia Island, FL; St. Petersburg, FL; Jacksonville, FL; and Pensacola, FL.
What destinations are included in Southeast U.S. cruises?
Southeast U.S. cruises visit a range of historic and coastal destinations along the Mid-Atlantic and southern East Coast and inland waterways. Depending on the itinerary, guests may explore cities such as Charleston, SC; Savannah, GA; Jacksonville, FL; St. Augustine, FL; Baltimore, MD; Annapolis, MD; and Washington, D.C., as well as scenic regions like the Chesapeake Bay, Intracoastal Waterway, and Florida Gulf Coast. Each itinerary is designed to highlight the history, culture, and natural beauty of the Southeast U.S.