Grand Ohio River Cruise
Pittsburgh, PA to St. Louis, MO
St. Louis, MO to Pittsburgh, PA
Join us for this enchanting adventure along the grand Ohio and Mississippi Rivers. From the quaint riverbanks of Ohio and Kentucky to the industrious spirit of Pittsburgh and the historic charm of St. Louis, each port demonstrates the spirit of America. Aboard one of our modern riverboats or classic paddlewheelers, learn about the pivotal eras of the Civil War and the Civil Rights Movement as you navigate these iconic waterways.
In Henderson, KY, explore the Audubon Museum, home to original artworks that illuminate the profound influence of John James Audubon on America’s appreciation for the natural world. Venture to the National Quilt Museum in Paducah, world-renowned for its extensive and beautifully curated collection of quilts and fiber art. In Louisville, experience the thrill of Churchill Downs, the heart of the Kentucky Derby, with an exclusive behind-the-scenes look at this hallowed ground of horseracing.
As the day comes to a close, retreat to the comfort of your ship. Dine in our refined restaurant, where culinary delights meet engaging conversation and each meal is inspired by the ports you visit.
Upcoming Dates & Fares
Itinerary & Excursions
*Exact itinerary & excursions will vary by cruise date
Map & Itinerary Overview
Experience two of America’s greatest rivers on this 16-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain.
Day 1 - Pittsburgh, PA
Long known for its steel manufacturing, Pittsburgh played a vital role in Ohio River commerce, becoming a prosperous center of trade and industry during the 18th and 19th centuries.
Settle into your hotel and enjoy time exploring this dynamic city at your leisure. Discover the stories of influential figures such as H.J. Heinz, Andrew Carnegie, and other visionaries who helped shape Pittsburgh’s legacy and left an enduring mark on American history.
Day 2 - Pittsburgh, PA
Board your ship, get settled in, and ready for the adventure ahead. As we set sail, watch the Ohio River begin to bend and wave goodbye to Steel City.
Cruise this scenic riverside route amid sweeping views of the Ohio River and delightful small towns along the way. As you wind through lush forests, gently rolling hills, and quiet valleys, delight in a peaceful escape from the bustle of city life. Pass through vibrant riverfront communities and admire glimpses of historic buildings and local marinas, each telling its own unique story.
Day 3 - Day of Cruising
Cruise at a relaxed pace along this scenic riverside route. From observation lounges, open-air decks, or private balconies, take in the changing landscapes and enjoy a peaceful escape from the bustle.
As you sail, onboard enrichment introduces the Ohio River’s important role in early settlement, river commerce, and the communities that flourished on its banks.
Approaching Marietta, the region’s rich heritage comes into view. One of the oldest settlements in the Northwest Territory, Marietta welcomes guests with well-preserved architecture, a storied riverfront, and a warm small-town atmosphere.
Day 4 - Marietta, OH
Nestled at the confluence of the Muskingum and Ohio Rivers, Marietta offers a fascinating glimpse into America’s early days. Founded in 1788 as the first permanent settlement in the Northwest Territory, this enchanting river town preserves its pioneering spirit through its historic architecture and a wealth of notable landmarks.
Guests can delve into Marietta’s remarkable past on a guided Earthworks Walking Exploration, viewing ancient Native American earthworks and learning about the mysteries, discoveries, and ongoing research surrounding these extraordinary sites.
The journey continues with a visit to the Castle Historic House Museum, a beautifully preserved 1855 Gothic Revival home steeped in local history. Step inside to discover fascinating stories from Marietta’s past while admiring its distinctive brickwork, elegant turret, ornate interiors, intricate woodwork, and carefully preserved period furnishings.
Day 5 - Day of Cruising
Today is all about carefree enjoyment as you settle into the relaxed rhythm of river cruising. Make the day your own while deepening your appreciation for the history, character, and hospitality that define the region. From expansive lounges to the sun deck, find a favorite spot to relax with a good book, take in the breeze, or simply watch the river go by.
Throughout the day, savor an array of onboard delights, from chef-inspired regional cuisine and signature cocktails to freshly baked daily treats. Engage with educational presentations that bring the river’s stories and surroundings to life, enjoy live entertainment, and share memorable moments with fellow travelers.
Day 6 - Maysville, KY
Discover the small-town charm and rich history of Maysville, one of the Ohio River’s most historically significant river towns. A narrated exploration reveals its connections to early American commerce, westward expansion, and the Underground Railroad.
Begin at the Kentucky Gateway Museum Center, where award-winning dioramas and fascinating artifacts bring the stories of explorers, artists, and movie stars to life. Then visit the Russell Theater, a beloved Maysville landmark opened in 1930 by businessman Colonel J. Barbour Russell. Learn about its connection to Maysville native Rosemary Clooney, whose film The Stars Are Singing premiered here in 1953, and admire memorabilia celebrating that memorable occasion. Saved from demolition by volunteers, the beautifully restored theater remains a cherished part of Maysville’s heritage and is listed on the National Register of Historic Places.
Day 7 - Cincinnati, OH
The dramatic bridges spanning the Ohio River provide a striking welcome to Cincinnati, a vibrant city with a storied past as an early shipbuilding and shipping metropolis. Known as the “Queen City,” Cincinnati blends old-world allure, cultural attractions, and a proud sporting legacy.
Experience the excitement of America’s favorite pastime with a private behind-the-scenes look at the Great American Ball Park, home of the Cincinnati Reds. Explore the clubs, seating bowl, dugouts, and more before visiting the Reds Hall of Fame and Museum to celebrate the legends of the game.
Delve into the history of the National Underground Railroad Freedom Center, where powerful exhibits illustrate the stories of courage, resilience, and determination that helped enslaved individuals seek freedom.
Day 8 - Madison, IN
A quaint town located on the banks of the Ohio River, Madison is one of the oldest and most captivating cities in the state, known for its well-preserved 19th-century architecture. Listed on the National Register of Historic Places, Madison features over 130 preserved buildings that showcase a mix of Greek Revival, Victorian, and Federal styles.
Experience Madison aboard a vintage-style trolley, enjoying fascinating stories, local landmarks, and a special visit to one of the town’s treasured churches. Later, discover Lanier, the “Crown Jewel” of Madison’s Historic District. Explore this 1844 Greek Revival mansion, learn about James F.D. Lanier’s legacy, and be treated to refreshing lemonade on the home’s grand porch or expansive lawn.
In the afternoon, step aboard a jet boat for an adventure on the Ohio River. As you cruise this picturesque waterway, the captain and crew will share local insights and help you spot wildlife along the way.
Day 9 - Louisville, KY
Louisville, a vibrant waterfront city nestled along the Ohio River, has played an important role in America’s history. For generations, the river shaped Louisville’s destiny, as boats were forced to stop where the Ohio’s rocky rapids interrupted their journey.
Step into the world of horseracing at the legendary Churchill Downs, home to the Kentucky Derby, the oldest continuously held horse race in the nation. For a slice of Americana, visit the Louisville Slugger Museum & Factory, where the iconic baseball bats are crafted.
No visit to Louisville would be complete without experiencing its famed bourbon heritage. Explore a local distillery as the aroma of aging spirits fills the air. Sip the refined flavors of Kentucky bourbons, each taste telling a story of craftsmanship and Bluegrass country.
Day 10 - Day of Cruising
The grand Ohio River invites you to embrace a slower, more immersive way of experiencing America’s heartland. Settle into the rhythm of the river as you take in stunning views and quaint riverside towns from the top deck. Savor the natural beauty of the Ohio River Valley and watch each changing vista unfold along the way.
Enrich your journey with onboard activities, from engaging presentations to lively discussions, that add depth and context to the landscapes around you. Sail through a region steeped in history, where every mile reveals a new chapter in the story of the Ohio River.
Day 11 - Henderson, KY / Evansville, IN
Discover the rich character of Henderson and Evansville, two distinctive Ohio River communities. In relaxed Henderson, uncover the legacy of naturalist and artist John James Audubon, who found creative inspiration here in the early 1800s while creating masterpieces for Birds of America. At the Audubon Museum and Nature Center, a park guide brings the artist’s life and work into focus. From there, take time to explore the museum’s galleries, wildlife observation room, theater, and Discovery & Learning Center at your own pace.
Just downriver, Evansville blends contemporary energy with historic charm. Visit the Evansville Wartime Museum, an excursion honoring the region’s armed forces and hometown heroes whose manufacturing contributions supported the Allied effort during World War II. Then, step inside the Reitz Home Museum for an elegant Victorian Tea Party while learning about its remarkable 1871 French Second Empire architecture.
Day 12 - Day of Cruising
As you cruise the Ohio River, keep watch for white-tailed deer, red foxes, cottontail rabbits, and other wildlife. From the water’s edge to forests and wetlands, the river supports a remarkable variety of plant and animal life.
Onboard enrichment offers a closer look at the Ohio River’s ecology, including conservation efforts that help protect its habitats and its importance to migratory bird populations. Learn how seasonal changes and waterways support wildlife throughout the region.
With every passing mile, discover the living countryside surrounding the river and gain a deeper appreciation for the delicate ecosystem that makes this scenic journey so captivating.
Day 13 - Paducah, KY
At the meeting point of the Tennessee River and the Ohio River lies Paducah, a designated UNESCO Creative City of Crafts and Folk Art. With the guidance of our seasoned local expert, delve into its layered history and evolving creative identity.
Explore the city’s Wall-to-Wall Floodwall Murals, a public art installation featuring more than 50 large-scale works depicting Native American heritage, pivotal Civil War moments, and local landmarks such as the Old Carnegie Library. Continue to the LowerTown Arts District, a 25-square-block neighborhood where restored buildings now house studios, galleries, and a thriving community of working artists.
Among Paducah’s cultural highlights, the National Quilt Museum stands out as a nationally recognized institution that attracts textile artists and design enthusiasts from across the country. Its exhibits celebrate the artistry, innovation, and cultural depth of quilting.
Day 14 - Day of Cruising
On your journey from the Ohio River to the Mississippi River, experience the unique opportunity to travel along two of America’s most iconic waterways on a single voyage. As you make your way toward St. Louis, watch the landscape evolve from the gentle hills and riverfront communities of the Ohio Valley to the distinctive scenery, cultures, and river environments of the Mississippi corridor. Between sweeping views from the top deck and peaceful moments on your private balcony, enjoy the changing countryside as it unfolds around you.
Take part in onboard activities, such as trivia sessions in the lounge, or simply relax and savor the panoramic river vistas. As you cruise toward St. Louis, appreciate the significance of this historic city, long regarded as a vital gateway connecting the Eastern United States with the American frontier. This transition offers a memorable perspective on the waterways that helped shape the nation.
Day 15 - St. Louis, MO
Approaching the banks of St. Louis, Missouri, the skyline and the Gateway Arch rise along the river, marking one of the major Midwestern cities where the Mississippi and Missouri Rivers meet. Located within Gateway Arch National Park, the Arch is the largest man-made monument in the U.S. and stands as a symbol of the nation’s westward expansion.
Immerse yourself in the city's wealth of world-class attractions on a guided journey through downtown. Take in the riverfront, Citygarden, Soulard, Lafayette Square, and Forest Park. Experience the iconic Gateway Arch, explore interactive exhibits, and ascend 630 feet for breathtaking panoramic views.
Then, visit the renowned Anheuser-Busch (Budweiser) facility to see the legendary Clydesdales’ stables, the historic Brewhouse, and the Beechwood Aging Cellars, where signature beers are crafted to perfection.
Day 16 - St. Louis, MO
Enjoy breakfast on board the ship as you prepare for your journey home. Reflect on the highlights of your voyage and the new friendships forged during your travels.
If you’re not quite ready to leave, extend your stay and explore the Gateway City further. Experience more of St. Louis’s vibrant neighborhoods, revisit favorite landmarks like the Gateway Arch, or immerse yourself in the local culture through museums, parks, and culinary delights.
Each Mississippi region itinerary comes complete with a Hotel Stay, where you can enjoy the city at your leisure. On the morning of the cruise, meet in the hotel lobby and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.
Explore this beautifully preserved, 1855 Gothic-Revival house which is on the National Register of Historic Places. The Castle was once home to some of Marietta's most prominent citizens and the site of many prestigious functions. Hear fascinating stories about its history and learn about of one of the oldest regions in the Northwest Territory.
Activity Level: Medium | ADA ACCESSIBLE: Yes
Explore the captivating museums of Marietta at your leisure with our convenient shuttle, making stops at:
- Campus Martius and Ohio River Museum - Explore America’s migration west, its earliest native inhabitants, and Marietta’s pioneers. Discover the golden age of the steamboat and learn more about the ecology of the Ohio River system. Outside the museum, visitors can take an escorted exploration of the WP SNYDER JR – the last intact, steam-powered “pool-type” stern-wheeled towboat in the United States.
- Children’s Toy & Doll Museum - Get a glimpse into what entertained and educated children in the late 19th and early 20th centuries. Explore nine rooms, displaying antique and vintage doll collections, including Kewpie dolls, Barbie dolls and GI Joe model dolls, miniature houses, as well as larger models of fairy tale homes such as the Ole’ Woman in the Shoe model and a Hansel and Gretel Gingerbread Doll House.
Activity Level: Low | ADA Accessible: Yes
When the first American settlers arrived at the juncture of the Muskingum and Ohio rivers, they observed an extensive and intriguing complex of earthen walls and mounds, leading to much speculation about how old they were, who built them, and to what purpose they were created. Over 230 years later, we have a general idea of when these earthworks were created and how they were used, even as many questions remain to be answered. Join Castle archaeologist Wes Clarke as we take a detailed look at these prehistoric remains, including significant new information that has been generated in recent years with modern research techniques. Visit the four principal surviving elements of the Marietta works, beginning at Mound Cemetery and driving to Capitolium, Quadranaou, and Sacra Via.
Activity Level: Moderate | ADA Accessible: Yes
Established in 1801 by Marietta city founders, the Mound Cemetery preserves the Great Mound (also known as Conus), a prehistoric Adena burial mound, with more American Revolutionary War officers buried in it than any other cemetery in the country. Led by a guide, explore this ancient ground and hear stories of Adena and Hopewell Mound Builders, Marietta founders, Revolutionary War veterans, and other historically significant Marietta residents.
Activity Level: Moderate | ADA Accessible: Yes
There are a variety of activities scheduled on board when the ship is underway, which vary depending on the itinerary and scheduled date. Enjoy destination-focused enrichment programs with special guest speakers who present topics related to the region and ports of call, including Art Classes, Cooking Demonstrations, Mixology (practice of making great cocktails), Trivia, Game Shows, and more.
Step back in time while you tour the historic town of Old Washington. Starting at the 1790s Visitor Center, your costumed guide will lead you through this historic Kentucky village, taking you along flagstone sidewalks graced with authentic frontier log cabins and early 19th-century homes.
Activity Level: High | ADA Accessible: Yes
Discover small town charm during a narrated exploration of historic Maysville. Begin at the Kentucky Gateway Museum Center, which brings the stories of explorers, artists, and movie stars to life through award-winning dioramas and a collection of artifacts.
Visit The Russell Theater, opened in 1930 by Colonel J. Barbour Russell, a flamboyant, well-known Maysville businessman who made his early fortune in the grocery business. The structure is constructed entirely of steel, concrete, brick, and terra cotta in Spanish Colonial style with a Moorish influence. This Theatre is atmospheric, and one of only two in Kentucky.
In 1953, Rosemary Clooney, a Maysville native, premiered her movie, The Stars Are Singing. Today, the lobby is dedicated to memorabilia of that night and other items of interest to Clooney fans. After nearly being torn down, The Russell Theater was saved by volunteers who donated countless hours restoring and preserving this heart of Maysville, which is listed in individually on the National Register of Historic Places.
Activity Level: Low | ADA Accessible: Yes
The National Underground Railroad Freedom Center celebrates the brave men and women who came together to create a secret network through which the enslaved could escape to freedom. Their examples of courage, cooperation, and perseverance, is relevant to this day, as we continue to deal with contemporary issues of equality and diversity.
Activity Level: Low | ADA Accessible: Yes
Explore both sides of the river on this fantastic, all-encompassing excursion. Begin in the heart of the city at Fountain Square. Along your journey, view the Contemporary Arts Center, Procter and Gamble’s International Headquarters, and the Taft Museum in beautiful Lytle Park. Learn about Cincinnati’s most well-known landmarks including: Union Terminal, Music Hall, Washington Park, Smale Riverfront Park, Bicentennial Commons, the new TQL Stadium, and the Paul Brown Stadium and Great American Ball Park – home of the Bengals and Reds.
Enjoy the old-world charm of Mount Adams with its “shot-gun” row homes and charming district of shops and restaurants. View picturesque Eden Park, home to the Cincinnati Art Museum, Playhouse in the Park, and Krohn Conservatory.
Cross the Ohio River to Kentucky’s historic Riverside Drive with its antebellum homes. Explore the entertainment district at Newport on the Levee and the World Peace Bell – the largest free-swinging bell in the world. While in Kentucky, you will enjoy a breathtaking view of the Cincinnati skyline.
Activity Level: Low | ADA Accessible: Yes
Explore the Cincinnati Art Museum, located in scenic Eden Park. Featured is a diverse, comprehensive art collection of more than 67,000 works spanning 6,000 years. In addition to displaying its own encyclopedic collection, the museum also hosts a variety national and international traveling exhibitions each year.
Activity Level: Low | ADA Accessible: Yes
Experience baseball history on this guided experience of the home of the Cincinnati Reds! Join our private Great American Ball Park Tour offering you a behind-the-scenes look at the clubs, seating bowl, dugouts, and more. You will also enjoy same day access to visit the Reds Hall of Fame and Museum. A must see for baseball fans.
Activity Level: Moderate | ADA Accessible: Yes
Enjoy discovering this remarkable destination at your own pace. Wander through beautifully landscaped grounds, encounter fascinating animal habitats, and admire the lush botanical displays that make this one of the region’s most distinctive attractions. With time to explore at your leisure, you can choose the exhibits and areas that interest you most while taking in the zoo’s unique blend of wildlife, nature, and conservation.
For a relaxing way to experience even more of the zoo, your visit also includes the opportunity to ride the train. Sit back and enjoy the journey as the train carries you through the grounds of this expansive attraction, offering a different perspective and access to areas you might otherwise miss.
Activity Level: Moderate to High | ADA Accessible: Yes
Visit the "Crown Jewel" of Madison's Historic District. Enjoy the opportunity to explore this 1844 Greek Revival mansion, a National Historic Landmark, and learn about James FD Lanier, his family, and his contributions to the State of Indiana. Afterwards, join us for lemonade as you relax on the magnificent porch or explore the expansive south lawn.
Activity Level: Low | ADA Accessible: Partial
Explore Madison's Historic Landmark District with a local expert. The enlightening walking exploration will provide a glimpse into Madison's rich history and exquisite architecture, which is the reason this town houses one of the country’s largest National Historic Landmark Districts. You'll be led through the heart of Madison and will conclude at The Attic Coffee Mill Cafe where you will be treated to a coffee and specially prepared pastry. The walk starts at the dock and ends at the Attic. A coach will be provided to bring you back to the ship if needed.
Activity Level: Moderate | ADA Accessible: Partial
Take the opportunity to explore history, shopping, and the culture of USA Today's Best Small Town in the Midwest. Don't miss the opportunity to walk on Main Street to find unexpected historical buildings, galleries, and boutiques. With more than 133 blocks of outstanding architecture, Madison’s downtown business district is one of the country’s largest National Historic Landmark Districts. Madison’s founders brought with them their own history, which is displayed in the architecture of the homes and buildings that make up this historic gem. Travel America says, “Madison is an outdoor museum of architecture.”
Activity Level: Low | ADA Accessible: Yes
Step aboard a vintage-style trolley for a delightful, guided excursion through the heart of historic Madison, Indiana. With a lively and knowledgeable guide leading the way, you’ll uncover the stories, architecture, and charm that make this river town truly one of a kind. Along the journey, enjoy scenic views, local landmarks, and a special stop at one of Madison’s most treasured historic churches.
Activity Level: Low | ADA Accessible: No
Get ready for an exhilarating jet boat ride on the Ohio River. As you cruise this beautiful stretch of one of America’s most legendary waterways, your experienced captain and crew will bring the river to life with local history and colorful insights into the communities and landscapes along its banks. Keep your eyes open for native wildlife as you travel through peaceful stretches of river framed by picturesque scenery. Sit back, take in the view, and enjoy the thrill of exploring this iconic waterway.
Activity Level: Low | ADA Accessible: No
Step into the home of Kentucky’s first distiller on historic Whiskey Row and experience the story of bourbon brought to life. Discover the heritage, craftsmanship, and bold character that have defined Evan Williams bourbon for generations. Enjoy a guided exploration of the distillery, followed by a tasting of their signature spirits. Afterward, browse the gift shop and the lobby exhibits at your leisure.
Activity Level: Low | ADA Accessible: Yes
Louisville Slugger is the maker of the world’s most popular bat. The company’s storied traditions and high standards for quality have produced some of the finest bats for amateurs and professionals alike. Take a guided tour of the facility and museum, learning first-hand their processes from forest-to-factory and the scientific principles used to fabricate the most important tool in “America’s Game.” Enjoy special seasonal exhibits and receive a free souvenir bat to commemorate your visit.
Activity Level: Moderate | ADA Accessible: Yes
Get a behind-the-scenes look at the world-famous Churchill Downs Racetrack. Walk through a portion of the grandstands where thousands of people roar with excitement on Derby Day. Your guide will lead you to the rail of the legendary dirt track where every Derby winner has raced, from Aristides to Secretariat and more. Have your camera ready for pictures of the historic track. Hear stories of the early days of the Kentucky Derby through its transformation into the event it is today. Enjoy a viewing of the epic film, The Greatest Race, a 360-degree, 18-minute media experience that will make your heart race and your emotions soar. Be treated to Mint Juleps and Derby Pie Bites as you listen to a special presentation by an actual Kentucky Derby Jockey who can answer any questions you may have about this iconic event.
Activity Level: Low | ADA Accessible: Yes
Discover Kentucky’s fascinating past, present, and future with exhibits like “The Spirit of Kentucky,” which demonstrates the history, craft, and culture of Kentucky Bourbon.
Explore the “Lewis and Clark Experience,” a one-of-a-kind exhibit that recreates Lewis and Clark’s 1804 mission. Find out “What’s Cool About Kentucky,” in an exhibit that illustrates the quirky, often surprising, and always authentic culture of Kentucky.
Activity Level: Low | ADA Accessible: Yes
The Audubon Museum and Nature Center interprets the life of John James Audubon through his art and personal memorabilia framed within a timeline of world events. Join a park naturalist on a guided tour before enjoying some free time to explore the Museum’s three galleries and the Center’s wildlife observation room, theater, and Discovery & Learning Center on your own.
Activity Level: Low | ADA Accessible: No
This unique museum celebrates the service of the Evansville region's armed forces, focusing on the manufacturing contributions made during World War II by the region's hometown heroes. Be treated to an exclusive exploration of the Main Hall and four galleries. The Home Front Gallery displays exhibits on the wartime munitions and personal military memorabilia, including uniforms, weapons, and honors. Also featured is the Evansville Canteen - having served the troops passing through on their way to war, an exhibit honoring the sacrifices made by nurses in the war, as well as period automobiles, and military equipment, such as a landing craft from the LST 325, an Evansville-built P-47 Thunderbolt fighter plane, and a 1943 M4A4 Sherman Tank, to name a few.
Activity Level: Low | ADA ACCESSIBLE: Yes
Vanderburgh County was thriving following the Civil War and this Courthouse was constructed in 1890 to function not only as a new, larger government building but also as a marketing tool to promote the area as a center of trade, manufacturing, agriculture, and education. Led by an expert guide, explore the rich history and architectural marvels of the Courthouse and campus, which is listed on the National Register of Historic Places. Outside of the Courthouse, admire the notable sculpture on the grounds. Commonly known as "The Genius of Electricity,” it is a larger-than-life figure of a man holding a light bulb, symbolizing the transformative power of electricity. Learn about the nearby jail, a former cemetery that was recently excavated, and how the grounds were once the site of a race riot 1903. As you move inside the courthouse, be greeted by an impressive neoclassical facade adorned with intricate detailing and towering columns. Admire a stunning central rotunda crowned by a breathtaking stained-glass dome. Your guide will explain the history of the building will be available to answer any questions you may have.
Discover the elegance of the Victorian era with a memorable visit to the Reitz Home Museum, beginning with a refined Victorian Tea Party in the Carriage House. Enjoy an inviting selection of tea and traditional fare while learning more about this remarkable home, an 1871 French Second Empire masterpiece recognized for its architectural and historical significance.
Following tea, continue into the beautifully preserved main residence, where an extraordinary mix of Victorian design styles, including Moorish, Renaissance, Gothic, and Eastlake influences, comes together in a stunning showcase of craftsmanship and artistry. Elaborate woodwork, intricate details, and richly appointed interiors offer an intimate glimpse into the sophistication and grandeur of 19th-century life.
Featured multiple times in Victorian Homes Magazine and often described as a “mini Biltmore,” the Reitz Home is a true gem and an unforgettable window into Evansville’s fascinating past. Guests will also have the opportunity to view an original Civil War flag, which was presented to the Reitz family.
Activity Level: Low | ADA Accessible: Partial
Experience Paducah at your leisure with convenient Cruise Coach service throughout the city. Stops include:
- The National Quilt Museum - Discover one of Paducah’s most celebrated cultural attractions. Admire striking works by renowned quilters who push the boundaries of fiber art through imaginative designs, techniques, and contemporary approaches.
- LowerTown Arts District & Neighborhood - Wander through this charming 25-block neighborhood, listed on the National Register of Historic Places and known for its beautifully preserved architecture. Look for the neighborhood directory at the iconic Texaco Station to help guide your exploration.
- Civil War Museum & Tilghman House - Step inside this remarkable 1852 Greek Revival home and hear the fascinating stories of Paducah’s role during the Civil War. Learn about the people and events that reveal the city’s strategic importance and significant influence during this pivotal period in America.
- Paducah Railroad Museum - Travel back to the golden age of American railroading at this engaging, interactive museum. View railroad equipment, artifacts, memorabilia, and hands-on exhibits that capture the romance and excitement of the railroads and their lasting impact on Paducah and the region.
- River Discovery Center - Explore Paducah’s deep connection to the rivers that have shaped its history and identity. Interactive, water-filled exhibits bring the region’s maritime heritage to life, including a working model of a lock and dam that demonstrates the fascinating engineering behind river navigation.
Activity Level: Low | ADA Accessible: Yes
Let our local guide take you through the quaint city of Paducah. This excursion has been carefully divided into three distinct sections to make sure you experience all that Paducah has to offer. First, explore the downtown as our local expert guide points out the areas’ many historical sites. Then, ride along the riverfront where you will witness more than 50 life-sized panoramic murals depicting elements of Paducah’s past. End at the National Quilt Museum, the world's largest museum devoted to quilts and fiber art.
Activity Level: Low | ADA Accessible: Yes
Escape to the countryside for a delightful visit to a local alpaca farm, where you’ll have the opportunity to meet these gentle, curious animals up close and enjoy a relaxing experience surrounded by nature.
Led by the owners of the farm, your visit offers a personal introduction to alpaca life and the unique world of raising these fascinating animals. Stroll through the property, meet the alpacas, and learn about their care, personalities, and the luxurious fiber they produce. After exploring the farm, take time to browse the onsite store, featuring a selection of beautifully crafted alpaca products, including soft, luxurious clothing and other distinctive items made from alpaca fiber.
Activity Level: Low | ADA Accessible: No
Relive the story of the Native Americans, explorers, pioneers, and rebels who made America possible. Featuring over 200 years of history within six themed exhibit areas, this innovative and interactive museum celebrates America’s pioneering spirit and explains the westward expansion of the U.S., with an emphasis on St. Louis’ role in that era.
Shaped by the inspired design of Finnish-America architect Eero Saarinen, the Gateway Arch monument celebrates the expansion West and the pioneers who made it possible. Since its completion in 1965, millions of visitors have taken a trip to the top to enjoy stunning views. Begin your adventure with our new, interactive pre-boarding exhibits featuring 60s-era animation and Gateway Arch trivia. Then, be transported 630 feet to the top of America’s tallest man-made monument. Or, if you prefer, enjoy the movie Monument to a Dream, which chronicles the construction of this national monument.
Activity Level: Low | ADA Accessible: Partial
This narrated exploration provides you with a wonderful overview of the city, including downtown St. Louis and the riverfront, Citygarden Sculpture Park, the historic neighborhoods of Soulard and Lafayette Square, Forest Park, and The Cathedral Basilica of St. Louis, a stunning church which rivals the cathedrals in Rome, Italy.
Activity Level: Low | ADA Accessible: Yes
Anheuser-Busch offers a unique and immersive experience, allowing visitors to explore the iconic Clydesdales stables, where the famous horses are housed, and the Beechwood Aging Cellars, where the company’s signature beers are aged to perfection. You will also see the historic Brewhouse, where brewing traditions date back over a century, and the Bevo Packaging facility, which showcases the advanced technology behind the packaging process. This comprehensive experience provides an in-depth look at the brewing legacy, craftsmanship, and innovation behind Anheuser-Busch a.k.a Budweiser.
Activity Level: Moderate | ADA Accessible: No
As one of the nation's leading art museums, the Saint Louis Art Museum is a great stop. The Museum collects, presents, interprets, and conserves more than 33,000 works of art across time and cultures. Explore the Egyptian, African, Native American, American and European art collections of the late 19th through early 21st centuries and visit the Contemporary collection in the David Chipperfield-designed East Building.
Activity Level: Moderate | Accessibility: Yes
Discover 79 acres of breathtaking landscapes, remarkable plant collections, and dazzling seasonal displays at the Missouri Botanical Garden, one of St. Louis’s most treasured cultural attractions. Wander through beautifully designed gardens and tranquil pathways as you admire an extraordinary variety of plants from around the world.
Find serenity in the Japanese Garden, with its peaceful water features and carefully cultivated plantings. Then travel into the tropics inside the Climatron, an iconic geodesic conservatory where lush rainforest vegetation, exotic plants, and a warm, humid atmosphere create the feeling of stepping into another world.
Activity Level: Moderate | ADA Accessible: Yes
Visit the largest museum in North America dedicated to a single artist. The Andy Warhol Museum holds an extensive permanent collection of art and archives from this Pittsburgh-born pop art icon. Explore the museum’s many galleries, which feature his paintings, photographs, unique prints, and sculptures, as well as Warhol films and videotaped works. A must-see for any art aficionado.
Please Note: This excursion is only available on cruises ending in Pittsburgh.
Named after Republican Politician Senator John Heinz, this interactive museum is full of six floors worth of Western Pennsylvania History, covering the past 250 years. Exhibits include the life of Senator John Heinz, the history of Pittsburgh, professional sports memorabilia, and much more.
Please Note: This excursion is only available on cruises ending in Pittsburgh.
Activity Level: Medium | ADA Accessible: Yes
Enjoy your locally guided experience exploring Pittsburgh, PA, ranked one of the most livable cities in America. Located at the confluence of three mighty rivers, this resilient city has reinvented itself through the years from a smoky industrial "Steel City" to a modern city of technology, culture, and world class hospitals and universities.
While on this excursion, travel through many of the city's unique neighborhoods and hear the colorful stories of what makes Pittsburgh, Pittsburgh. Enjoy an exploration of Pittsburgh's South Side and former Steel mill sites, as well as its Eastern neighborhoods, including Millionaire's Row, and the Downtown Golden Triangle. In the Northside, enjoy the iconic sites in Pittsburgh's playground, home to Heinz Field, PNC Park, and the National Aviary. And of course, no visit to the city would be complete without a stop atop Mount Washington to view the spectacular Pittsburgh Skyline.
Activity Level: Low | ADA Accessible: Yes
Explore the home of the Pittsburgh Steelers with an exciting behind-the-scenes look at Acrisure Stadium. Step beyond the stands and into the places where football history, tradition, and game-day excitement come together.
Your guided stadium experience includes access to the Field Level, where you can take in the atmosphere from a player’s perspective, as well as a visit to the Steelers Locker Room for an insider’s look at where the team prepares for game day. Continue through the impressive FedEx Great Hall, filled with the energy of Steelers football, and be sure to see the famous Heinz Ketchup Bottle displayed above Gate C, one of the stadium’s most recognizable features.
During this engaging excursion, enjoy plenty of opportunities to learn more about the Steelers, Acrisure Stadium, and the traditions that have made the team one of the NFL’s most iconic franchises. Following your stadium exploration, delight in free time to browse the official team store and shop for Steelers apparel, memorabilia, and souvenirs to commemorate your visit.
Activity Level: Moderate | ADA Accessible: Yes
Map & Itinerary Overview
Experience two of America’s greatest rivers on this 16-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain.
Day 1 - St. Louis, MO
Enjoy a relaxing hotel stay and explore the city at your leisure before embarking on your cruise. Take in the striking skyline as it unfolds along the river, crowned by the iconic Gateway Arch, a defining landmark of one of the Midwest’s most celebrated cities, where the Mississippi and Missouri Rivers converge.
Visit Gateway Arch National Park, home to the Arch which stands as a symbol of the nation’s westward expansion. Discover downtown St. Louis, taking in the riverfront, Citygarden, Soulard, Lafayette Square, and Forest Park, or visit the renowned Anheuser-Busch (Budweiser) brewery to see the legendary Clydesdales.
Day 2 - Cruising the Mississippi River
Board the ship and begin your travels along the Mississippi River toward Hannibal. From the sun deck, take in small towns and agricultural stretches that reflect the working landscape of this region.
Take time to get comfortable in your stateroom and admire the scenery from your private balcony. Or participate in onboard enrichment activities that highlight the culture and history of the river. Don’t miss cocktail hour, a chance to meet fellow travelers, before enjoying dinner inspired by local flavors.
Day 3 - Paducah, KY
At the meeting point of the Tennessee River and the Ohio River lies Paducah, a designated UNESCO Creative City of Crafts and Folk Art. With the guidance of our seasoned local expert, delve into its layered history and evolving creative identity.
Explore the city’s Wall-to-Wall Floodwall Murals, a public art installation featuring more than 50 large-scale works depicting Native American heritage, pivotal Civil War moments, and local landmarks such as the Old Carnegie Library. Continue to the LowerTown Arts District, a 25-square-block neighborhood where restored buildings now house studios, galleries, and a thriving community of working artists.
Among Paducah’s cultural highlights, the National Quilt Museum stands out as a nationally recognized institution that attracts textile artists and design enthusiasts from across the country. Its exhibits celebrate the artistry, innovation, and cultural depth of quilting.
Day 4 - Day of Cruising
As you cruise the Ohio River, keep watch for white-tailed deer, red foxes, cottontail rabbits, and other wildlife. From the water’s edge to forests and wetlands, the river supports a remarkable variety of plant and animal life.
Onboard enrichment offers a closer look at the Ohio River’s ecology, including conservation efforts that help protect its habitats and its importance to migratory bird populations. Learn how seasonal changes and waterways support wildlife throughout the region.
With every passing mile, discover the living countryside surrounding the river and gain a deeper appreciation for the delicate ecosystem that makes this scenic journey so captivating.
Day 5 - Henderson, KY / Evansville, IN
Discover the rich character of Henderson and Evansville, two distinctive Ohio River communities. In relaxed Henderson, uncover the legacy of naturalist and artist John James Audubon, who found creative inspiration here in the early 1800s while creating masterpieces for Birds of America. At the Audubon Museum and Nature Center, a park guide brings the artist’s life and work into focus. From there, take time to explore the museum’s galleries, wildlife observation room, theater, and Discovery & Learning Center at your own pace.
Just downriver, Evansville blends contemporary energy with historic charm. Visit the Evansville Wartime Museum, an excursion honoring the region’s armed forces and hometown heroes whose manufacturing contributions supported the Allied effort during World War II. Then, step inside the Reitz Home Museum for an elegant Victorian Tea Party while learning about its remarkable 1871 French Second Empire architecture.
Day 6 - Day of Cruising
The grand Ohio River invites you to embrace a slower, more immersive way of experiencing America’s heartland. Settle into the rhythm of the river as you take in stunning views and quaint riverside towns from the top deck. Savor the natural beauty of the Ohio River Valley and watch each changing vista unfold along the way.
Enrich your journey with onboard activities, from engaging presentations to lively discussions, that add depth and context to the landscapes around you. Sail through a region steeped in history, where every mile reveals a new chapter in the story of the Ohio River.
Day 7 - Louisville, KY
Louisville, a vibrant waterfront city nestled along the Ohio River, has played an important role in America’s history. For generations, the river shaped Louisville’s destiny, as boats were forced to stop where the Ohio’s rocky rapids interrupted their journey.
Step into the world of horseracing at the legendary Churchill Downs, home to the Kentucky Derby, the oldest continuously held horse race in the nation. For a slice of Americana, visit the Louisville Slugger Museum & Factory, where the iconic baseball bats are crafted.
No visit to Louisville would be complete without experiencing its famed bourbon heritage. Explore a local distillery as the aroma of aging spirits fills the air. Sip the refined flavors of Kentucky bourbons, each taste telling a story of craftsmanship and Bluegrass country.
Day 8 - Madison, IN
A quaint town located on the banks of the Ohio River, Madison is one of the oldest and most captivating cities in the state, known for its well-preserved 19th-century architecture. Listed on the National Register of Historic Places, Madison features over 130 preserved buildings that showcase a mix of Greek Revival, Victorian, and Federal styles.
Experience Madison aboard a vintage-style trolley, enjoying fascinating stories, local landmarks, and a special visit to one of the town’s treasured churches. Later, discover Lanier, the “Crown Jewel” of Madison’s Historic District. Explore this 1844 Greek Revival mansion, learn about James F.D. Lanier’s legacy, and be treated to refreshing lemonade on the home’s grand porch or expansive lawn.
In the afternoon, step aboard a jet boat for an adventure on the Ohio River. As you cruise this picturesque waterway, the captain and crew will share local insights and help you spot wildlife along the way.
Day 9 - Cincinnati, OH
The dramatic bridges spanning the Ohio River provide a striking welcome to Cincinnati, a vibrant city with a storied past as an early shipbuilding and shipping metropolis. Known as the “Queen City,” Cincinnati blends old-world allure, cultural attractions, and a proud sporting legacy.
Experience the excitement of America’s favorite pastime with a private behind-the-scenes look at the Great American Ball Park, home of the Cincinnati Reds. Explore the clubs, seating bowl, dugouts, and more before visiting the Reds Hall of Fame and Museum to celebrate the legends of the game.
Delve into the history of the National Underground Railroad Freedom Center, where powerful exhibits illustrate the stories of courage, resilience, and determination that helped enslaved individuals seek freedom.
Day 10 - Day of Cruising
Today is all about carefree enjoyment as you settle into the relaxed rhythm of river cruising. Make the day your own while deepening your appreciation for the history, character, and hospitality that define the region. From expansive lounges to the sun deck, find a favorite spot to relax with a good book, take in the breeze, or simply watch the river go by.
Throughout the day, savor an array of onboard delights, from chef-inspired regional cuisine and signature cocktails to freshly baked daily treats. Engage with educational presentations that bring the river’s stories and surroundings to life, enjoy live entertainment, and share memorable moments with fellow travelers.
Day 11 - Maysville, KY
Discover the small-town charm and rich history of Maysville, one of the Ohio River’s most historically significant river towns. A narrated exploration reveals its connections to early American commerce, westward expansion, and the Underground Railroad.
Begin at the Kentucky Gateway Museum Center, where award-winning dioramas and fascinating artifacts bring the stories of explorers, artists, and movie stars to life. Then visit the Russell Theater, a beloved Maysville landmark opened in 1930 by businessman Colonel J. Barbour Russell. Learn about its connection to Maysville native Rosemary Clooney, whose film The Stars Are Singing premiered here in 1953, and admire memorabilia celebrating that memorable occasion. Saved from demolition by volunteers, the beautifully restored theater remains a cherished part of Maysville’s heritage and is listed on the National Register of Historic Places.
Day 12 - Day of Cruising
Cruise at a relaxed pace along this scenic riverside route. From observation lounges, open-air decks, or private balconies, take in the changing landscapes and enjoy a peaceful escape from the bustle.
As you sail, onboard enrichment introduces the Ohio River’s important role in early settlement, river commerce, and the communities that flourished on its banks. Approaching Marietta, the region’s rich heritage comes into view. One of the oldest settlements in the Northwest Territory, Marietta welcomes guests with well-preserved architecture, a storied riverfront, and a warm small-town atmosphere
Day 13 - Marietta, OH
Nestled at the confluence of the Muskingum and Ohio Rivers, Marietta offers a fascinating glimpse into America’s early days. Founded in 1788 as the first permanent settlement in the Northwest Territory, this enchanting river town preserves its pioneering spirit through its historic architecture and a wealth of notable landmarks.
Guests can delve into Marietta’s remarkable past on a guided Earthworks Walking Exploration, viewing ancient Native American earthworks and learning about the mysteries, discoveries, and ongoing research surrounding these extraordinary sites.
The journey continues with a visit to the Castle Historic House Museum, a beautifully preserved 1855 Gothic Revival home steeped in local history. Step inside to discover fascinating stories from Marietta’s past while admiring its distinctive brickwork, elegant turret, ornate interiors, intricate woodwork, and carefully preserved period furnishings.
Day 14 - Day of Cruising
Cruise along the Ohio River toward Pittsburgh, enjoying a leisurely journey through one of America’s most iconic waterways. As you make your way toward this historic river city, watch the scenery unfold, from gentle hills and wooded banks to charming riverfront communities and scenic valleys. Take in the panoramic vistas from the top deck or retreat to your private balcony for a peaceful moment surrounded by river views.
Throughout the day, join in onboard activities such as trivia sessions in the lounge, or simply relax and enjoy the unhurried rhythm of river cruising. As you approach Pittsburgh, appreciate the significance of a city shaped by the confluence of three rivers and its important role in American industry, commerce, and westward expansion.
Day 15 - Pittsburgh, PA
Pittsburgh offers a fascinating finale to your Ohio River journey. Once a powerhouse of steel manufacturing and a vital center for national and international commerce, the city grew into a thriving 18th and 19th-century industrial hub. Today, the “Steel City” has transformed into an established destination known for its technology, culture, universities, and world-class medical institutions.
Discover Pittsburgh’s remarkable evolution on a locally guided experience through some of the neighborhoods and popular sights that define the city’s character. Explore the South Side, once home to bustling steel mills and now a district blending history and modern attractions.
Travel through the elegant streets of Millionaire’s Row, lined with grand mansions reflecting Pittsburgh’s prosperous industrial era, before visiting the Downtown Golden Triangle, the heart of the city where three rivers meet. Continue to the North Side, home to celebrated cultural and sporting landmarks, before ascending Mount Washington for breathtaking panoramic views of Pittsburgh’s dramatic skyline and riverfront.
Day 16 - Pittsburgh, PA
After breakfast on board, begin your journey home with memories of welcoming river towns, idyllic scenery, and unforgettable moments along the Ohio River. Reflect on the connections made through shared excursions, onboard activities, and time spent with fellow guests and crew.
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Grand Ohio River Cruise FAQs
What is the Grand Ohio River cruise?
The Grand Ohio River cruise is a 16-day voyage connecting the Ohio and Mississippi rivers, with itineraries available between Pittsburgh and St. Louis in either direction. The journey offers an opportunity to experience the scenic beauty, history, and culture of America's heartland while visiting a variety of river towns and communities along the way.
Which destinations will I visit on the Grand Ohio River cruise?
The itinerary features a variety of destinations along the Ohio and Mississippi rivers, from historic cities to charming river towns. Each destination offers guided excursions that provide opportunities to discover the region's history, architecture, culture, and local character.
What is included with the Grand Ohio River cruise?
Our cruise includes accommodations aboard one of our modern riverboats or paddlewheelers, all meals and beverages, a hotel stay and transportation to the ship, at least one excursion in every port, access to our signature nightly cocktail hour, onboard entertainment, and all port fees and gratuities.
Who would enjoy the Grand Ohio River cruise?
This itinerary is ideal for travelers interested in American history, river culture, scenic landscapes, and the communities along the Ohio and Mississippi rivers. It's a great choice for guests who enjoy a longer cruise with a balance of relaxing days on the water and engaging shore excursions.