Ohio River Cruise

Pittsburgh, PA to St. Louis, MO

St. Louis, MO to Pittsburgh, PA

11 Days / 10 Nights

Cruise Overview

Experience two of America’s greatest rivers on this 11-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain. The Ohio River was pivotal in the development and exploration of the American West and along the way we highlight much that has defined our American roots from the Civil War to bluegrass music. Or, you can take a milder pace and just kick back with a rocking chair and a glass of sweet tea on the sun deck while American Cruise Lines handles the rest. 

Each port of call showcases a new element of Americana. In Henderson, for instance, you may visit the John James Audubon Museum, which features many original works and join our expert guide to learn about the sense of natural wonder that Audubon instilled in so many Americans. While in Louisville, we are treated to a behind the scenes tour of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery, each destination with a distinct American story to tell. 

Every cruise on the Ohio River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and, as it has been since the dawn of river travel, our sailing schedules must adapt to it. It is possible that guests will be transported between a town on the Ohio River and Pittsburgh by coach for excursions or embarkation. 

Ask about our Current Savings and our Complimentary Pre-cruise Packages which include a premium hotel stay and transportation to the ship. Click the Schedules & Rates tab for details.

Ohio River Cruise Itinerary


Inaugurated 2015
Guest Capacity 150
Rooms 84
Common Areas 6
View Dates & Fares See Details
Arrow back to cruise details
Dates & Fares

Ohio River Cruise

11 Days - 10 Nights One Way 11 Ports of Call

Load More

Other Cruises on the Mississippi River

Grand Heartland Cruise

St. Paul, MN to New Orleans, LA

15 Days / 14 Nights
View Cruise Details

New Orleans - New Orleans

New Orleans, LA to New Orleans, LA

8 Days / 7 Nights
View Cruise Details