Ohio River Cruise

Pittsburgh, PA to St. Louis, MO

St. Louis, MO to Pittsburgh, PA

11 Days / 10 Nights
From $5,620

Cruise Overview

Experience two of America’s greatest rivers on this 11-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain. The Ohio River was pivotal in the development and exploration of the American West and along the way we highlight much that has defined our American roots from the Civil War to bluegrass music. Or, you can take a milder pace and just kick back with a rocking chair and a glass of sweet tea on the sun deck while American Cruise Lines handles the rest. 

Each port of call showcases a new element of Americana. In Henderson, for instance, you may visit the John James Audubon Museum, which features many original works and join our expert guide to learn about the sense of natural wonder that Audubon instilled in so many Americans. While in Louisville, we are treated to a behind the scenes tour of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery, each destination with a distinct American story to tell. 

Every cruise on the Ohio River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and, as it has been since the dawn of river travel, our sailing schedules must adapt to it. It is possible that guests will be transported between a town on the Ohio River and Pittsburgh by coach for excursions or embarkation. 

Ask about our Current Savings and our Complimentary Pre-cruise Packages which include a premium hotel stay and transportation to the ship. Click the Schedules & Rates tab for details.

Ohio River Cruise Itinerary

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  • Inaugurated 2015
  • Rooms 84
  • Guest Capacity 150
  • Common Areas 6

Deck Plans

Ship Deck

Queen of the Mississippi

113 115 117 114 116 118 Dining Room V estibule Galley Elev.

Deck Plan 1

Ship Deck

Queen of the Mississippi

202 204 206 212 214 216 218 220 222 203 205 207 209 211 213 215 217 219 221 V estibule Ship’sOffice Magnolia Lounge L ounge Elev.

Deck Plan 2

Ship Deck

Queen of the Mississippi

301 302 308 310 312 316 318 320 322 324 326 328 330 332 329 331 327 325 323 321 319 317 315 313 311 309 304 306 303 305 307 V estibule Chart Room Elev.

Deck Plan 3

Ship Deck

Queen of the Mississippi

401 403 405 407 409 411 413 415 417 419 402 404 406 408 410 414 416 418 420 V estibule Sky Lounge Fitness Room Elev.

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Queen of the Mississippi

509 511 513 502 504 506 508 510 512 Pilothouse Sun Deck PuttingGreen Elev.

Deck Plan 5

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Dates & Fares

Ohio River Cruise

11 Days - 10 Nights One Way 11 Ports of Call

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