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American Cruise Lines offers a variety of captivating cruise itineraries throughout the United States, including the Mississippi River region, Southeast, Northeast, Pacific Northwest, and Alaska.

Mississippi River Cruises

New England Cruises

Pacific Northwest & Alaska Cruises

Southeast Cruises

Themed Cruises

Music Cruise

Music Cruise

Delight in the sounds of Jazz and Blues that fill the air as we cruise the Mississippi River and...

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The American Cruise Lines Difference

Delicious Cuisine
Gracious Service
Nightly Entertainment
First Class Staterooms