Grand Heartland Cruise

St. Paul, MN to New Orleans, LA

New Orleans, LA to St. Paul, MN

15 Days / 14 Nights

Cruise Overview

Enjoy an epic 15-day journey on our Grand Heartland Cruise. This cruise on the Mississippi River travels from the northern reaches of St. Paul all the way down to the basin in New Orleans.

View the dramatic landscapes of the Upper Mississippi River which have long inspired artists, writers, and steamboat passengers. Visit Hannibal, the hometown of Mark Twain where the characters in his most popular works come to life. Immerse yourself in the culture of Memphis, the mid-South's most vibrant city, famous for Blues and BBQ.

As you journey down the river, hear stories about southern life on the plantation and tour historic Civil War sites led by our local area experts. On your final stop, New Orleans, enjoy privileged access to its vibrant music scene and the best in Cajun and Creole cuisine.  

Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.   

Click here to learn how American Harmony, the second in our series of new modern riverboats, is revolutionizing U.S. river cruising. 

Grand Heartland Cruise Itinerary


Inaugurated 2021
Guest Capacity 175
Rooms 91
Common Areas 6
Inaugurated 2016
Guest Capacity 185
Rooms 98
Common Areas 6
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Dates & Fares

Grand Heartland Cruise

15 Days - 14 Nights One Way 15 Ports of Call

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