Great Lakes & Thousand Islands Cruise
Syracuse, NY to Buffalo, NY
Buffalo, NY to Oswego, NY
Embark on a scenic journey through the Thousand Islands, an archipelago of over 1,800 islands dotted with storybook castles and tree-lined shores. In Clayton, discover maritime history at the renowned Antique Boat Museum, then savor the flavors of a local vineyard as you can taste signature wines and learn the art of winemaking from grape to glass.
Continue to Ogdensburg, a tranquil gateway to the St. Lawrence River, before heading to Rochester, where history comes alive at the Susan B. Anthony House, celebrating the life and legacy of this pioneering activist. Enjoy a leisurely day cruising across the vast expanse of Lake Ontario, followed by a journey through the engineering marvel of the Welland Canal, which connects Lakes Ontario and Erie.
Conclude your adventure in Buffalo, where you can admire the shores of Lake Erie, explore the revitalized Canalside waterfront, and experience the awe-inspiring beauty of Niagara Falls.
Upcoming Dates & Fares
Itinerary & Excursions
*Exact itinerary & excursions will vary by cruise date
Map & Itinerary Overview
Cruise the scenic Thousand Islands, tour Clayton’s Antique Boat Museum, and transit the Welland Canal before concluding in Buffalo with a visit to Niagara Falls for an unforgettable encounter with naturer's power.
Day 1 - Syracuse, NY
Arrive in Syracuse for your hotel stay. Once a major hub of the Erie Canal, the city’s history is etched into landmarks like Clinton Square, framed by 19th-century buildings. Visit the Erie Canal Museum to learn about the region’s role in shaping America’s growth or enjoy a relaxed evening sampling the city’s farm-to-table dining before your cruise begins.
Day 2 - Day of Cruising
Board in nearby Oswego and settle into your stateroom. As you sail into Lake Ontario, enjoy time exploring your ship. Take in the crisp lake air from the sun deck, listen to enrichment talks about the St. Lawrence River’s maritime legacy, or simply relax with fellow travelers as your journey gets underway.
Day 3 - Clayton, NY
Cruise into the scenic Thousand Islands, where castles and Gilded Age mansions crown wooded isles. In Clayton, explore the Antique Boat Museum, where varnished mahogany shines under museum lights, or tour Boldt Castle, a romantic stone estate built on Heart Island. Every view here seems to sparkle with water, pine, and history.
Day 4 - Day of Cruising
Sail west across Lake Ontario. Spend the day enjoying onboard amenities, attend a lecture on canal engineering, sample regional wines, or watch lighthouses and fishing boats drift past.
Day 5 - Ogdensburg, NY
Enjoy this scenic and peaceful gateway to the St. Lawrence River and the heart of the Thousand Islands region. As one of the northernmost ports in New York State, Ogdensburg sits directly on the U.S.-Canada border, offering stunning views of the river and easy access to the natural beauty of upstate New York.
Explore a variety of cultural and historic attractions that highlight the area’s rich heritage. The Frederic Remington Art Museum, dedicated to the iconic American Western artist, is a must-see, featuring a remarkable collection of his sculptures, paintings, and personal artifacts. Outdoor enthusiasts can stroll along the riverfront, visit local parks, or take short excursions to the nearby Thousand Islands for sightseeing and boating.
Day 6 - Rochester, NY
Dock in Rochester, birthplace of Kodak and the modern camera. Tour the George Eastman Museum, where landscaped gardens surround the grand mansion of the photography pioneer, or hear the roar of High Falls, a 96-foot cascade that once powered the city’s flour mills. Rochester’s legacy of invention and artistry is evident on every street.
Day 7 - Day of Cruising the Welland Canal
Transit the Welland Canal, one of North America’s greatest engineering achievements. As your ship is raised and lowered nearly 100 feet between Lakes Ontario and Erie, watch the lock gates close and feel the vessel slowly climb, step by step. Guides on board share the canal’s history, from early construction to modern freight traffic.
Day 8 - Buffalo, NY
Arrive in Buffalo, where history meets modern revival. Experience the revitalized Canalside waterfront, indulge in the city’s famous Buffalo wings, or take a trip to Niagara Falls, just a short distance away.
Architecture enthusiasts can admire the city’s rich legacy, from Art Deco gems like City Hall to the historic mansions lining Delaware Avenue. In the evening, catch a sunset cruise along Lake Erie or visit one of Buffalo’s craft breweries for a taste of the local scene.
Day 9 - Buffalo, NY
After breakfast on board the ship, take in the final views from the deck. As you disembark, carry with you the new friendship and the experiences that made your trip truly special.
Enjoy a 1-night hotel stay, breakfast, and transportation to the ship. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.
As you board the ship, be welcomed by the crew who will ensure that every detail of your journey is seamless. Take the time to meet fellow travelers, share stories, and immerse yourself in the relaxed atmosphere of small-ship cruising.
From panoramic deck views to thoughtfully designed lounges, every corner of the ship offers a chance to relax, socialize, and prepare for the memorable adventures that await.
A visit to Boldt Castle offers a captivating journey through a historic love story set in the heart of the Thousand Islands. Guests can explore the beautifully restored rooms, grand staircases, and scenic balconies overlooking the St. Lawrence River. The lush gardens and peaceful surroundings make for perfect photo opportunities and a relaxing day trip. Don't miss the Power House and the Yacht House, which showcase fascinating architecture and historic craftsmanship.
Activity Level: Low | ADA Accessible: Yes
Explore the best of the Thousand Islands aboard the Clayton Shuttle, your easy, hop-on-hop-off ride to the village’s top attractions.
- The Antique Boat Museum – Explore the premier freshwater boating museum in North America. Admire beautifully restored wooden boats, elegant runabouts, and classic racing crafts.
- Thousand Islands Museum – Step back in time as you explore the museum’s wide range of displays spanning well over a century. Discover stories of river pirates, fishing guides, and the famous River Rat Hall of Fame.
- Downtown Clayton – Peruse unique boutiques, art galleries, cozy cafés, and waterfront restaurants that capture the charm of river life.
Activity Level: Low | ADA Accessible: Yes
Discover the rich history and waterfront charm of Clayton on a guided walk through one of the most storied communities in the Thousand Islands region. Learn how tourism transformed the area into a premier vacation destination while uncovering fascinating stories of legendary shipbuilders, notable river captains, and the grand historic homes they once occupied. Visit Thousand Islands Museum and the renowned Antique Boat Museum, where the region’s maritime heritage comes to life. Gain insight on how the elegant hotels, resorts, and railroad connections fueled Clayton’s growth and popularity, before enjoying free time to stroll through the vibrant downtown shopping district.
Activity Level: High | ADA Accessible: Yes
Experience the Thousand Islands Winery with a guided tour and tasting. Walk through the vineyard and production areas to learn how award-winning wines are crafted from grape to bottle, then sample a selection of local favorites. Taste their signature Saint Lawrence Red, the cold-hardy Marquette, crisp Riesling, and smooth Chardonnay, among others. Set against scenic vineyard views and a relaxed, welcoming atmosphere, it’s an inviting way to discover the distinctive flavors and heritage of the Thousand Islands region.
Activity Level: Low | ADA Accessible: Yes
Climb aboard a glass bottom boat to travel to Rock Island Lighthouse and experience the beauty and history of the Thousand Islands like never before. Glide over the clear waters of the St. Lawrence River as you peer through glass panels to see fascinating underwater landscapes, shipwrecks, and marine life below. Upon arrival, step ashore at Rock Island Lighthouse, where you can explore the historic keeper’s quarters, climb the tower for breathtaking views, and learn about the life of a 19th-century lighthouse keeper.
Activity Level: Low - Moderate | ADA Accessible: Partial
Step inside the Clayton Opera House and uncover the history, architecture, and stories behind this iconic community landmark. Built in the early 19th century, the Opera House has hosted everything from theatrical productions to concerts, lectures, and town gatherings. Explore its beautifully preserved interior, learn about its role in Clayton’s cultural life, and hear tales of the performers and audiences who brought the space to life. Perfect for history buffs and arts enthusiasts alike, the Clayton Opera House Tour offers a glimpse into the heart of the village’s performing arts legacy.
Activity Level: Low | ADA Accessible: Yes
There are a variety of activities scheduled on board when the ship is underway, which vary depending on the itinerary and scheduled date. Enjoy destination-focused enrichment programs with special guest speakers who present topics related to the region and ports of call, including Art Classes, Cooking Demonstrations, Mixology (practice of making great cocktails), Trivia, Game Shows, and more.
Step into the heart of North Country heritage at this engaging museum, housed in the elegant 1810 Parish Mansion. The museum showcases the vivid, spirited works of celebrated artist Frederic Remington, whose depictions of the American frontier continue to captivate and inspire. With engaging exhibitions, hands-on programs, and a commitment to welcoming audiences of all ages, the museum is a destination where art, history, and the enduring legacy of the West converge.
Activity Level: Low | ADA Accessible: Yes
Enjoy a guided visit to the historic 28-acre Fort de la Présentation, where the Revolutionary War era comes to life. Explore an authentic encampment staffed by reenactors in period dress and experience hands-on demonstrations including soldier equipment displays, campfire cooking, musket drills, and artillery exercises. Learn about the fort’s origins as a British outpost and its strategic role in the conflicts that shaped the region’s history. The experience also includes time to explore the scenic grounds and walk the Abbé Piquet Trail, offering additional insight into the fort, its surrounding landscape, and the people who once lived and served there.
Activity Level: Moderate | ADA Accessible: Yes
Step into the past on a guided walk along Washington Street led by the city historian and discover Ogdensburg’s rich heritage up close. Stroll past striking architectural landmarks like the Parish Mansion, the Bishop’s Residence, and the Spratt and Hannan Houses as you take in their unique design details and craftsmanship. Along the way, hear captivating stories that reveal both the inspiring and darker chapters of the city’s history, bringing to life the people and events that shaped this vibrant community.
Activity Level: Moderate / ADA Accessible: Partial
Discover Ogdensburg at your own pace with convenient Cruise Coach transportation to the Ogdensburg Museum. Enjoy a leisurely stroll through this welcoming riverside destination, where local atmosphere and sweeping views of the St. Lawrence River set the tone.
Along the waterfront, peaceful walking paths, benches, and open green spaces invite you to relax and watch boat traffic drift by. Downtown, a mix of independently owned shops, cafés, and casual eateries adds to the town’s laid-back charm.
Activity level: Low / ADA Accessible: Yes
Step into the heart of the women’s suffrage movement at this beautifully preserved National Historic Landmark where history was not only made, it was lived. Once the home of Susan B. Anthony, one of America’s most influential civil rights leaders, it also served as the headquarters of the National American Woman Suffrage Association during her presidency. It was here that Anthony was famously arrested in 1872 for casting a ballot in a federal election, an act of defiance that became a pivotal moment in the fight for women's voting rights. The home also holds deep personal significance as the place where Anthony gave countless speeches, hosted fellow reformers, and eventually passed away in 1906, shortly after delivering her rousing “Failure is Impossible” address. Today, visitors can explore the home’s original furnishings, powerful exhibits, and guided tours that bring her courageous legacy to life.
Activity Level: Moderate | ADA Accessible: Partial
Embark on a relaxing cruise along the Genesee River aboard the historic vessel Riverie, where you can sit back, unwind, and take in the natural beauty of Rochester’s scenic waterways. Travel to the famous Erie Canal, which celebrated its bicentennial in 2025, and pass through Lock 33, one of only two active locks in the area. Along the way, enjoy live guided narration highlighting the storied past of the Genesee River and the Erie Canal, as well as an engaging explanation of how canal locks operate.
Activity Level: Low | ADA Accessible: Yes
Step back in time at one of the nation’s largest living history museums. Stroll through a meticulously recreated 19th-century village, where beautifully restored buildings and costumed interpreters bring the past to life. Watch skilled artisans demonstrate traditional crafts and take part in hands-on activities that provide insight into daily life in early America. Set amid scenic grounds, this immersive experience offers a memorable connection to the stories, skills, and traditions that shaped an era.
Activity level: Moderate / ADA Accessible: Partial
The George Eastman Museum, located in the former home of Kodak founder George Eastman, is the world’s oldest museum dedicated to photography and motion pictures. Visitors can explore stunning galleries featuring groundbreaking photographic art, pioneering film history, and rotating exhibitions that inspire creativity. The beautifully preserved Colonial Revival mansion and its elegant gardens showcase a captivating glimpse into Eastman’s life and legacy.
Activity level: Low / ADA Accessible: Yes
A day cruising the Welland Canal immerses you in the history and innovation that shaped Great Lakes travel. Completed in 1829 to link Lake Ontario and Lake Erie, the canal enabled ships to bypass Niagara Falls and transformed Great Lakes shipping.
As you journey through its impressive lock system, witness ships being lifted and lowered with remarkable precision. Scenic shorelines and close-up views of towering freighters create an unforgettable experience that highlights both the region’s past and its ongoing maritime importance.
Experience the awe of Niagara Falls like never before from the U.S. side, where adventure meets unforgettable views. Start your journey at the Observation Tower, offering sweeping panoramas of all three majestic waterfalls. Then, feel the thunder of the falls aboard the world-famous Maid of the Mist, where you'll cruise into the heart of the mighty Horseshoe Falls. For the ultimate thrill, venture into the Cave of the Winds, where wooden walkways bring you just feet from the crashing Bridal Veil Falls on the exhilarating Hurricane Deck. It’s a one-of-a-kind encounter with nature’s power.
Activity Level: Moderate | ADA Accessible: Partial
Experience the Buffalo AKG Art Museum like never before on a guided exploration that brings art to life. Named one of TIME’S World's Greatest Places in 2024, the museum showcases an exceptional collection of modern and contemporary art within striking architectural spaces. During your excursion, expert guides share the stories behind works by celebrated artists such as Vincent van Gogh, Pablo Picasso, Claude Monet, Jackson Pollock, Andy Warhol, and Salvador Dalí. The experience continues with a plein air watercolor session on the museum’s lawn, where guests create their own landscape paintings inspired by the surroundings.
Activity Level: Low | ADA Accessible: Yes
Discover America’s naval legacy at this naval and military park along Buffalo’s scenic waterfront. Explore engaging museum exhibits that feature artifacts, photographs, and uniforms that highlight the people and moments that shaped U.S. naval history. The experience also includes access to three historic vessels: the USS Little Rock, a guided-missile cruiser and former flagship of the U.S. Navy’s Sixth Fleet; the USS The Sullivans, a decorated World War II destroyer honoring the five Sullivan brothers; and the USS Croaker, a Cold War–era submarine offering a fascinating look at life beneath the waves.
Activity Level: High | ADA Accessible: Partial
Step into the world of Frank Lloyd Wright on a guided architectural journey through Buffalo, a city shaped by his bold and visionary designs. Begin with a drive past the historic Fontana Boathouse along the shores of Lake Erie, a striking example of Wright’s enduring influence. Continue with an in-depth visit to the stunning Frank Lloyd Wright Martin House, one of his greatest achievements and a masterpiece of innovative design. The experience concludes at Forest Lawn Cemetery with a stop at the remarkable Blue Sky Mausoleum, a powerful tribute that reflects Wright’s lasting legacy in Buffalo.
Activity Level: Low - Moderate | ADA Accessible: Yes
Explore Buffalo’s vibrant waterfront on a guided walk through Canalside, where history and architecture meet along the city’s original harbor. Stroll along the Canalside Boardwalk, pass the historic General Mills building, and take in the impressive DL&W Terminal. Along the way, cross the iconic Whipple Truss Bridge while your guide shares stories of Buffalo’s industrial past, architectural landmarks, and the transformation of this lively waterfront district.
Activity Level: High | ADA Accessible: Yes
Step into this lush indoor oasis, where vibrant plant life flourishes year-round across 12 interconnected greenhouses. With an expert guide, explore the gardens in depth—from the towering palms in the grand Palm Dome to colorful orchids, unusual carnivorous plants, and tranquil bonsai. Stroll through tropical and desert landscapes and discover plant species from around the world. Watch koi fish glide through tranquil waters. After the excursion, enjoy time to wander at your own pace and browse the unique offerings in the gift shop.
Activity Level: Moderate | ADA Accessible: Partial
Why not stay an extra night or two to immerse yourself in the spirit of this vibrant city? Ask your onboard Hotel General Manager for recommendations on area hotels, attractions, and more.
Enjoy a 1-night hotel stay with breakfast included. Before embarkation, delight in a memorable morning at Niagara Falls, on an exploration that brings you up close to its thundering cascades and sweeping views.
Once you've taken in the majesty of this iconic landmark, you’ll be comfortably transferred to the ship, setting the tone for the unforgettable journey ahead. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.
Led by a knowledgeable local guide, discover the beauty of Letchworth State Park, famously known as the “Grand Canyon of the East.” Carved by the Genesee River over thousands of years, the park features dramatic cliffs, lush forests, and a series of waterfalls that create some of the most spectacular landscapes in New York State.
Enjoy photo stops at several of the park’s most celebrated viewpoints, including Mount Morris Dam, Hogsback Overlook, and Inspiration Point as your guide shares insights into the park’s geology, history, and natural significance.
After, be treated to lunch at the historic Glen Iris Inn, the former country estate of park founder William Pryor Letchworth. Visit to the Humphrey Nature Center, offering interactive exhibits and a deeper look at the region’s wildlife and ecosystems. For those seeking a bit of light adventure, an optional one-mile flat walking trail is available, providing an opportunity to further experience the park’s peaceful landscapes at a relaxed pace.
Activity Level: Moderate / ADA Accessible: No
Take advantage of this shuttle service into Rochester to explore the city at your own pace. Featured stops include:
• Genesee Brew House & High Falls – Visit this beautifully restored 1904 brewery overlooking the dramatic 96-foot waterfall on the Genesee River. Enjoy locally crafted beers and scenic views of one of Rochester’s most iconic natural landmarks.
• Parkleigh – Browse this beloved Park Avenue gift shop known for locally made goods, artisan foods, specialty sweets, home décor, and Rochester-themed souvenirs. The surrounding neighborhood also features charming boutiques and specialty shops ideal for leisurely exploration.
• F. Oliver’s – Enjoy a delicious tasting experience featuring premium olive oils, aged balsamic vinegars, gourmet pantry items, and specialty foods sourced from around the world. Sample a variety of flavors while learning about pairing techniques and culinary uses.
• George Eastman Museum – Discover one of the world’s leading museums dedicated to photography and cinema during as you explore the historic mansion and galleries of George Eastman, the photography pioneer and founder of Kodak.
Activity Level: Low / ADA Accessible: Partial
Discover this beautifully preserved 19th-century mansion, operated by the Oswego County Historical Society. Built in 1867, it showcases elegant Victorian architecture, intricate woodwork, and period furnishings that bring the lifestyle of a prosperous family vividly to life. Visitors can wander through rooms filled with antiques, artwork, and exhibits highlighting regional heritage. When the home was gifted to the Society in 1946, it included most of the family’s original furnishings along with significant historic and ethnographic collections.
Activity Level: Low | ADA Accessible: Partial
Discover the character, flavors, and history of Oswego on this guided walk that pairs local cuisine with stories from the city’s past. Stroll through the heart of downtown while exploring notable landmarks such as the Municipal Plaza, Oswego City Hall, Fifth Street, and the Cahill Building. Along the way, gain insight into the people, architecture, and events that shaped this vibrant waterfront community. The experience is complemented by curated tastings of sweet and savory specialties from favorite local eateries, offering an authentic taste of Oswego’s culinary scene and warm hospitality.
Activity Level: High | ADA Accessible: Yes
This is a Signature shore excursion and should be reserved in advance. Please call (800) 894-8570 for information.
Step into Oswego’s living history at Fort Ontario State Historic Site and the Safe Haven Holocaust Refugee Shelter Museum, two landmarks that tell powerful stories of courage, resilience, and hope. Overlooking Lake Ontario, Fort Ontario has stood guard since the 1700s—its stone walls, barracks, and breathtaking views bringing centuries of military history to life. Just next door, the Safe Haven Museum preserves the inspiring story of nearly 1,000 Holocaust refugees who found sanctuary here during World War II—the only shelter of its kind in the United States. Together, these sites offer a moving journey through America’s past, where every artifact and exhibit connects visitors to the people and events that shaped Oswego and the world.
Activity Level: Moderate | ADA Accessible: Partial
Board this convenient shuttle making stops at:
H. Lee White Maritime Museum - Waterfront Museum in Oswego that preserves and showcases the rich maritime history of Lake Ontario through engaging exhibits on Great Lakes navigation, shipbuilding, and Oswego’s vital role as a port city.
West 2nd Street - Lively downtown destination with a mix of local boutiques, cafés, and small businesses that reflect the city’s waterfront charm.
Riverside Artisans - Cooperative gallery and shop showcasing handmade works by regional artists, offering everything from crafts and jewelry to locally inspired art.
Activity level: Low / ADA Accessible: Partial
Map & Itinerary Overview
Cruise the scenic Thousand Islands, tour Clayton’s Antique Boat Museum, and transit the Welland Canal before concluding in Buffalo with a visit to Niagara Falls for an unforgettable encounter with naturer's power.
Day 1 - Buffalo, NY
Begin your journey with a complimentary hotel stay in Buffalo, where historic architecture meets modern revival. Visit Frank Lloyd Wright’s Darwin Martin House, an Arts and Crafts masterpiece, or stroll the redeveloped Canalside district, where former grain silos now house breweries and art installations.
On the morning of embarkation, begin your adventure at the breathtaking Niagara Falls. Feel the mist, hear the roar, and take in the sheer power of this natural wonder before your cruise even begins. Afterward, relax as you’re transported to the ship, where your journey continues in comfort and style.
Day 2 - Day of Cruising
Spend the day getting acquainted with life on the water. Enjoy panoramic views from the observation deck as Lake Erie stretches out around you. On board, take part in enrichment programs led by our expert guides, or simply relax with a cocktail in hand as the ship glides toward your next destination.
Day 3 - Day of Cruising the Welland Canal
Transit the Welland Canal, one of North America’s greatest engineering achievements. As your ship is raised and lowered nearly 100 feet between Lakes Ontario and Erie, watch the lock gates close and feel the vessel slowly climb, step by step. Guides on board share the canal’s history, from early construction to modern freight traffic.
Day 4 - Rochester, NY
Dock in Rochester, birthplace of Kodak and the modern camera. Tour the George Eastman Museum, where landscaped gardens surround the grand mansion of the photography pioneer, or hear the roar of High Falls, a 96-foot cascade that once powered the city’s flour mills. Rochester’s legacy of invention and artistry is evident on every street.
Day 5 - Clayton, NY
Cruise into the scenic Thousand Islands, where castles and Gilded Age mansions crown wooded isles. In Clayton, explore the Antique Boat Museum, where varnished mahogany shines under museum lights, or tour Boldt Castle, a romantic stone estate built on Heart Island. Every view here seems to sparkle with water, pine, and history.
Day 6 - Day of Cruising
Sail west across Lake Ontario. Spend the day enjoying onboard amenities, attend a lecture on canal engineering, sample regional wines, or watch lighthouses and fishing boats drift past.
Day 7 - Ogdensburg, NY
Enjoy this scenic and peaceful gateway to the St. Lawrence River and the heart of the Thousand Islands region. As one of the northernmost ports in New York State, Ogdensburg sits directly on the U.S.-Canada border, offering stunning views of the river and easy access to the natural beauty of upstate New York.
Explore a variety of cultural and historic attractions that highlight the area’s rich heritage. The Frederic Remington Art Museum, dedicated to the iconic American Western artist, is a must-see, featuring a remarkable collection of his sculptures, paintings, and personal artifacts. Outdoor enthusiasts can stroll along the riverfront, visit local parks, or take short excursions to the nearby Thousand Islands for sightseeing and boating.
Day 8 - Oswego, NY
Get a unique glimpse into the maritime heritage and small-town charm found along the southern shore of Lake Ontario. Known as the “Port City,” Oswego has played an important role in Great Lakes commerce for centuries and is home to one of the oldest freshwater ports in the United States. Explore historic sites that reflect the area's military and shipping past, or stroll along a scenic waterfront featuring local shops and cafés. Museums in the area showcase the region’s nautical legacy, including shipwrecks, lighthouse history, and commercial shipping. Oswego also holds a unique place in American history as a haven for refugees during World War II. With its rich history, walkable waterfront, and warm community spirit, Oswego offers both cultural depth and a relaxing atmosphere along the journey.
Day 9 - Oswego, NY
Disembark in this picturesque city, offering a relaxed and memorable end to your Great Lakes journey. American Cruise Lines provides complimentary transportation to the Syracuse Hancock International Airport or you may choose to extend your stay, enjoying a final stroll along the waterfront or exploring Oswego’s cultural and historical offerings.