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Cruising the Mississippi River and its tributaries is an exploration of the American spirit with American Cruise Lines. We travel along the entire length of the Mississippi, Ohio and Cumberland Rivers with programs highlighting everything from music to Civil War History. Our paddlewheelers are the newest riverboats in the USA and cruise from New Orleans, Memphis, Nashville, Pittsburgh, St. Louis, and St. Paul.

Mississippi River Cruises

Complimentary Pre-Cruise Hotel

Pre-Cruise Hotel Package

Plus Save $400 when you reserve 9 months in advance
Call 800.460.4518 for additional details.

The American Cruise Lines Difference

Historic Destinations
Historic Destinations
cuisine
Delicious Cuisine
tiles_service
Gracious Service
entertainment
Nightly Entertainment