Memphis - St. Louis Cruise

Eight-Day Riverboat Cruise
Departing from St. Louis, MO or Memphis, TN

Journey to the heart and soul of America on American Cruise Lines’ Queen of the Mississippi.  As you enjoy the rhythms of the churning river, you’ll explore Civil War and Underground Railroad sites, visit the most haunted city in America, and discover quintessential small-town America.

Ports of Call: Memphis, New Madrid, Paducah, Cape Girardeau, Chester, St. Louis

Complimentary Pre-Cruise Hotel Package
on 2016 Mississippi River Cruises*
*Valid on new bookings only. Expires April 4, 2016.
Call 800.460.4518 for additional details.


Click on Images Above to View Photo Gallery

 St. Louis - Memphis Cruise Map Travel from the banks of Tennessee up to the heart of St. Louis on this wonderfully enlightening voyage, featuring stops in Paducah and Chester.

Cruise Highlights


New Madrid


Cape Girardeau


St. Louis



Day 1
Memphis, TN

Elvis Presley's Cadillac

Excitement resonates as you reach America’s third-largest inland port, famous for blues, barbeque, and Elvis Presley's Graceland. Less-touted attractions, such as the Pink Palace and Mud Island’s River Walk, replicating 1,000 miles of Mississippi River history and geography along an intriguing six-block stroll, are just as intriguing. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop for it all.

Day 2
New Madrid, MO

New Madrid Museum on Memphis to Nashville cruise

Originally founded in 1776, Spain traded New Madrid to France in 1800 who in turn sold it to the United States in 1803 as part of the Louisiana Purchase. Today, New Madrid is a living monument to early American history with sites including the Kochtitsky Home and the Trail of Tears and Veterans Park. 

Day 3
Paducah, KY

Kentucky Riverboat Cruise Excursions

Paducah, KY, became a major travel destination in 1991, when the National Quilt Museum opened its doors in the city. Every year, more than 40,000 quilting enthusiasts visit the Museum to see a wide variety of exhibits. For fans of art, Paducah’s LowerTown is home to a successful artist relocation program, where you can participate in creative workshops and discussions with professional artists.

Day 4
Day of River Cruising

Continue down the river as we leave Kentucky and make our way to Cape Girardeau, MO. Leisure and relaxation abound on this lovely stretch of the Mississippi River.


Day 5
Cape Girardeau, MO

Mississippi River Cruise Missouri Excursions

Enjoy the charming features of this historic town that was once a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

Day 6
Chester, IL

Grand Heartland Cruise
Chester is a beautiful region of Illinois located on the bluffs of the Mississippi River. This city has a diverse and storied history, beginning with the establishment of a ferry system by Jane Thomas in the early 1800s. Chester is home to Popeye's creator Elzie C. Segar and you may see the Sailor Man's likeness in the town's own six-foot-tall bronze metal statue

Day 7
Day of River Cruising

Upper Mississippi scenery aboard St Louis to Memphis cruise

Enjoy cruising as we make our way from Illinois to Missouri. This part of your journey offers an excellent chance to see the beauty of the Mississippi River's middle region.


Day 8
St. Louis, MO

Visit Gateway Arch During Mississippi River Cruise

Reflect upon the role St. Louis played in the opening of the American frontier as you cruise past the famed Gateway Arch Riverfront, the tallest man-made monument in the U.S. Get settled in and acquainted at a festive cocktail event with a welcome from the captain as you prepare for a trip down the Mississippi to the Ohio River, one of the most picturesque waterways in the country.

Mississippi River Cruises

Beneath the gleaming woodwork and brass fixtures aboard Queen of the Mississippi is a framework of modern cruise ship technology that provides passengers with the most comfortable vacation imaginable as we cruise the Mississippi and Ohio Rivers from New Orleans to Minneapolis or Cincinnati, OH. The Queen of the Mississippi features the most spacious staterooms in the industry and provides more space per passenger than any other river cruise ship.Click play to see more.

Date # of Nights Departure Location Ship

Queen of the Mississippi

Queen of the Mississippi delivers an experience unlike any other riverboat. Queen of the Mississippi offers passengers modern amenities and comforts including large staterooms with private balconies, hotel-style bathrooms, complimentary room service, WiFi, and more. Special Pricing now available: Call 800-460-4518 for details.

  • Rate Schedule Per Person:  7 Nights: 
  • Owner's Suite w/ Balcony $7,560
  • AAM w/ Balcony $6,275
  • AAC w/ Balcony $6,025
  • AAL w/ Balcony $5,875
  • A $4,540
  • Single w/ Balcony $6,740
  • Single $6,130

Rates subject to change


America is American Cruise Lines' latest paddlewheeler and sailed her maiden voyage in May of 2016. Designed with traditional Victorian-style accents, it elegantly blends a traditional appearance with modern features and amenities. While the new ship is adorned with gleaming woodwork, brass fixtures, and histoic decor, it is constructed with the latest in cruise ship technology. 

  • Rate Schedule Per Person:  7 Nights: 
  • Owner's Suite w/ Balcony $7,560
  • AAM w/ Balcony $6,275
  • AAC w/ Balcony $6,025
  • AAL w/ Balcony $5,875
  • A $4,540
  • Single w/ Balcony $6,740
  • Single $6,130

Rates subject to change

 Complimentary pre-night hotels are only valid on cruises booked 60-days prior to departure

US Paddlewheeler Cruises

Upper Mississippi River Cruise

This 8-day cruise features sprawling natural preserves and vivid American towns that bring you back to an earlier time on the river. Stops include the National Mississipi River Museum and Aquarium and Mark Twain's boyhood home in Hannibal, MO.  


Memphis - St. Louis Cruise

Enjoy an eight-day cruise rolling on the river as we cruise from Memphis, the home of blues, barbecue and Graceland to St. Louis, the adventurous city where westward expansion began. 


New Orleans Round Trip Cruise

Explore the heart of the Deep South on this 8-day cruise that takes you to intriguing ports-of-call including Natchez, St. Francisville, Houmas House and Baton Rouge.


Memphis - Nashville Cruise

Spend eight days travelling the Mississippi and Cumberland rivers from Memphis to Nashville including stops in Paducah, KY, Dover, TN and Clarksville, TN. 

Queen of the Mississippi Virtual Tour