Memphis - St. Louis Cruise

Eight-Day Riverboat Cruise
Departing from St. Louis, MO or Memphis, TN

Journey to the heart and soul of America on American Cruise Lines’ Queen of the Mississippi.  As you enjoy the rhythms of the churning river, you’ll explore Civil War and Underground Railroad sites, visit the most haunted city in America, and discover quintessential small-town America.

Ports of Call: Memphis, New Madrid, Paducah, Cape Girardeau, Chester, St. Louis

Click on Images Above to View Photo Gallery

 St. Louis - Memphis Cruise Map Travel from the banks of Tennessee up to the heart of St. Louis on this wonderfully enlightening voyage, featuring stops in Paducah and Chester.

Cruise Highlights


New Madrid


Cape Girardeau


St. Louis



Day 1
Memphis, TN

Elvis Presley's Cadillac

Excitement resonates as you reach America’s third-largest inland port, famous for blues, barbeque, and Elvis Presley's Graceland. Less-touted attractions, such as the Pink Palace and Mud Island’s River Walk, replicating 1,000 miles of Mississippi River history and geography along an intriguing six-block stroll, are just as intriguing. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop for it all.

Day 2
New Madrid, MO

New Madrid Museum on Memphis to Nashville cruise

Originally founded in 1776 by Spanish Governor Esteban Rodriguez, early settlers of New Madrid were required to become citizens of Spain in order to reside here. Spain traded the territory to France in 1800 who in turn sold it to the United States in 1803 as part of the Louisiana Purchase. Today, New Madrid is a living monument to early American history with sites including the Kochtitsky Home, the Trail of Tears and Veterans Park. The oldest American city west of the Mississippi River, New Madrid bridges classic southern heritage with the pioneering spirit that moved settlers westward. 

Day 3
Paducah, KY

Kentucky Riverboat Cruise Excursions

Paducah, KY, became a major travel destination in 1991, when the National Quilt Museum opened its doors in the city. Every year, more than 40,000 quilting enthusiasts visit the Museum to see a wide variety of exhibits. For fans of art, Paducah’s LowerTown is home to a successful artist relocation program, where you can participate in creative workshops and discussions with professional artists.

Day 4
Day of River Cruising

Queen of the Mississippi continues down the river as we leave Kentucky and make our way to Cape Girardeau, MO. Leisure and relaxation abound on this lovely stretch of the Mississippi River.


Day 5
Cape Girardeau, MO

Mississippi River Cruise Missouri Excursions

Enjoy the charming features of this historic town that was once a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

Day 6
Chester, IL

Mississippi River cruises

Chester is a beautiful region of Illinois located on the bluffs of the Mississippi River. This city has a diverse and storied history, beginning with the establishment of a ferry system by Jane Thomas in the early 1800s. Chester is home to Popeye's creator Elzie C. Segar and you may see the Sailor Man's likeness in the town's own six-foot-tall bronze metal statue

Day 7
Day of River Cruising

Upper Mississippi scenery aboard St Louis to Memphis cruise

Enjoy cruising as Queen of the Mississippi makes its way from Illinois to Missouri. This part of your journey offers an excellent chance to see the beauty of the Mississippi River's middle region.


Day 8
St. Louis, MO

Visit Gateway Arch During Mississippi River Cruise

Reflect upon the role St. Louis played in the opening of the American frontier as you cruise past the famed Gateway Arch Riverfront, the tallest man-made monument in the U.S. Get settled in and acquainted at a festive cocktail event with a welcome from the captain as you prepare for a trip down the Mississippi to the Ohio River, one of the most picturesque waterways in the country.

Mississippi River Cruises

Beneath the gleaming woodwork and brass fixtures aboard Queen of the Mississippi is a framework of modern cruise ship technology that provides passengers with the most comfortable vacation imaginable as we cruise the Mississippi and Ohio Rivers from New Orleans to Minneapolis or Cincinnati, OH. The Queen of the Mississippi features the most spacious staterooms in the industry and provides more space per passenger than any other river cruise ship.Click play to see more.

Date # of Nights Departure Location Ship
Jul 9, 2016 7 Memphis, TN Queen of the Mississippi reserve now
Jul 23, 2016 7 Memphis, TN America reserve now
Jul 22, 2017 7 Memphis, TN America reserve now

Queen of the Mississippi

Queen of the Mississippi delivers an experience unlike any other riverboat. Queen of the Mississippi offers passengers modern amenities and comforts including large staterooms with private balconies, hotel-style bathrooms, complimentary room service, WiFi, and more. 
Rate Schedule Per Person A AAL AAC AAM Owner's Suite Single w/ Balcony Single
7 Nights $4,540 $5,875 $6,025 $6,275 $7,560 $6,740 $6,130

Rates subject to change


The America will be American Cruise Lines’ eighth ship and its second brand-new vessel this year. Scheduled to begin sailing the Mississippi River in early 2016, America will be the finest Mississippi paddlewheeler ever built, introducing features never before seen on a Mississippi riverboat.
Rate Schedule Per Person A AAL AAC AAM Owner's Suite Single w/ Balcony Single
7 Nights $4,540 $5,875 $6,025 $6,275 $7,560 $6,740 $6,130

Rates subject to change

American Eagle

The brand new American Eagle made its debut on the Mississippi River in May of 2015. The 150-person capacity paddlewheeler features design elements reminiscent of an earlier time on the river coupled with a surprising assortment of modern luxuries. Spacious staterooms, fine furnishings, and private balconies are among the welcoming features which make the American Eagle comparable to your favorite world class hotels. 
Rate Schedule Per Person A AAL AAC AAM Owner's Suite Single w/ Balcony Single
7 Nights $4,540 $5,875 $6,025 $6,275 $7,560 $6,740 $6,130

Rates subject to change

Other Mississippi River Cruises

Upper Mississippi River Cruise

Eight Days cruising the dramatic landscapes of the upper Mississippi River, including stops in the iconic Davenport, MO and Hannibal, MO – Mark Twain’s childhood hometown. 


Memphis - St. Louis Cruise

Enjoy an eight-day cruise rolling on the river as we cruise from Memphis, the home of blue, barbecue and Graceland to St. Louis, the adventurous city where westward expansion began. 


New Orleans Round Trip Cruise

Explore the heart of the Deep South on this 8-day cruise that takes you to intriguing ports-of-call including Natchez, St. Francisville, Houmas House and Baton Rouge.


Memphis - Nashville Cruise

Spend eight days travelling the Mississippi and Cumberland rivers from Memphis, TN to Nashville, KY, including stops in Paducah, KY; Dover, TN and Clarksville, TN. 

Queen of the Mississippi Virtual Tour