Mississippi River Cruises

From northern Minnesota to its mouth at the Gulf of Mexico, the Mississippi River offers a uniquely American cruise experience. With more than 50 years’ experience and a fleet of 5 ships ranging from steamboat-style paddlewheelers to the newest modern luxury riverboats, American Cruise Lines is the leading operator of Mississippi River cruises. 

Our 12 unique itineraries provide guests more ways to explore the Mississippi than any other cruise line, while the sophisticated comfort of our modern riverboats offers the largest staterooms, private balconies, and complimentary excursions at every port.

Receive Free Airfare & Savings up to $1,500* on select Lower Mississippi River Cruises. Expires July 31, 2024.

Filter By:
Filter By:
× Clear Selections
× Clear Selections
We’re sorry, your search did not produce any results.

Historic Mississippi River Cruise

New Orleans, LA to New Orleans, LA

Free Airfare* Plus Save up to $1,000
8 Days / 7 Nights
From
$3,535

Lower Mississippi River Cruise

Memphis, TN to New Orleans, LA

Free Airfare* Plus Save up to $1,500
9 Days / 8 Nights
From
$4,295
$3,795

Upper Mississippi River Cruise

St. Louis, MO to St. Paul, MN

Save up to $1,000
9 Days / 8 Nights
From
$4,610

Music Cities Cruise

Memphis, TN to Nashville, TN

Free Airfare* Plus Save up to $1,000
9 Days / 8 Nights
From
$4,610
$4,210

Tennessee Rivers Cruise

Chattanooga, TN to Nashville, TN

Free Airfare* Plus Save up to $1,200
9 Days / 8 Nights
From
$4,295
$3,795

Mississippi Explorer Cruise

New Orleans, LA to Memphis, TN

Free Airfare* Plus Save up to $1,200
12 Days / 11 Nights
From
$5,995

Ohio River Cruise

Louisville, KY to Pittsburgh, PA

Free Airfare* Plus Save up to $1,000
9 Days / 8 Nights
From
$4,530
$4,030

Great Smoky Mountains National Park

Knoxville, TN to Nashville, TN

12 Days / 11 Nights
From
$7,110

Complete Mississippi River Cruise

New Orleans, LA to St. Paul, MN

Free Airfare* Plus Save up to $4,000
23 Days / 22 Nights
From
$15,890
$13,890

Grand Heartland Cruise

St. Paul, MN to New Orleans, LA

Save up to $1,200
16 Days / 15 Nights
From
$10,440
$9,840

Mississippi River Gateway Cruise

New Orleans, LA to St. Louis, MO

Free Airfare* Plus Save up to $1,200
12 Days / 11 Nights
From
$6,245
$5,645

Grand Ohio River Cruise

Pittsburgh, PA to St. Louis, MO

Free Airfare* Plus Save up to $2,000
16 Days / 15 Nights
From
$7,685
$6,685

*Offer Valid Only on New Bookings on Select Dates

Mississippi River Excursions

Embark on an unforgettable journey with American Cruise Lines as we navigate the vibrant waterways on one of our Mississippi River Cruises. Experience the unique charm and cultural richness of cities like New Orleans, Baton Rouge, and Memphis, each offering a glimpse into America's storied past and musical heritage.

America's Most Awarded Mississippi River Cruise Line

What Sets Us Apart

Made For You: A Personalized Mississippi River Cruise

Our Modern Riverboats are the newest ships on the Mississippi River. With a guest capacity of 180, our ships promise a more personalized experience than any other cruise line. Crew on American Cruise Lines can get to know you throughout your stay. We pay attention to you and your preferences to ensure your voyage is perfect for you. Our Paddlewheelers, with a classic Americana look, offer guests an authentic and nostalgic journey. Our onboard experts become a part of the experience as they travel with you and narrate your venture both on board and on shore. You’ll even be able to dine with your expert along the way.

Unique Excursions, Local Guides

From New Orleans, LA to St. Paul, MN, enjoy well-customized excursions, led by engaging local guides who live and work in these great port cities of America’s Heartland. Get a backstage pass to Elvis’ Graceland and the legendary Sun Studio in Memphis. Explore the boyhood town of Mark Twain in Hannibal and be treated to a live show at the Grand Old Opry in Nashville.

Onboard Experience

Get ready to jive where jazz, blues, and rock 'n' roll were born. Our amazing onboard musicians will keep you entertained with tunes that echo the river's soul. Feast on the best Cajun and Creole dishes and classic Memphis BBQ, all crafted by our top-notch chefs. Listen to our onboard experts bring the stories of the river to life at every port of call. Each evening, join us for a complimentary cocktail hour, perfect for swapping stories with fellow travelers over a refreshing mint julep. Cheers to unforgettable moments.

All-Inclusive Cruising

No matter which ship you choose, you’ll be staying in the largest stateroom in the industry. With private balconies and numerous common areas, you’ll have the perfect spot to watch the lively banks of this historic river roll by. Everything you’ll need is included with your cruise fare. All food, drinks (including beer, wine, and spirits), gratuities, and featured excursions are at no additional cost to you. And, to make your cruise experience truly all-inclusive, select itineraries offer Free Airfare and premium Pre-Cruise Packages that include a hotel stay and transportation to the ship. So, go ahead, enjoy yourself and see this amazing river in a whole new way, without reaching for your wallet.

Spacious Accommodations

Whether on board a modern riverboat or newly refurbished paddlewheeler, American Cruise Lines is proud to offer the largest staterooms in the industry, with full-size bathrooms, and private balconies offering the perfect vantage point from which to admire the scenic rolling river views. Guests can also look forward to discovering spacious lounges and quiet nooks to gather with fellow travelers.